| 1 | Margaret | Murry | Protagonist. aka: Meg, Meglet. |
| | Sandy | Murry | Denny's twin brother. Meg's brother. |
| | Denny | Murry | Sandy's twin brother. Meg's brother. |
| | Charles W. | Murry | Meg's baby brother. |
| | Fortinbras | | The big black dog. |
| | Mrs. | Buncombe | The constable's wife. |
| | Mrs. | Murry | Meg's mother. Scientist and doctor. |
| | Henderson | | The boy Meg beat up. |
| | Mrs. | Whatsit | A woman who lives in the Haunted House. |
| 2 | Mr. | Jenkins | Principal. |
| | Ms. | Porter | Teacher. |
| | Calvin | O'Kefee | Meg's schoolmate. Basketball varsity. |
| 3 | Mrs. | Which | A woman with an authoritative voice. Mrs. Whatsit's friend. |
| 4 | | | Uriel - Third planet of the Star Malak in the Spiral Nebula Messier. |
| 5 | | | Evil - A power of darkness. |
| | | | The Happy Medium - A woman with a crystal ball in Planet Uriel. |
| 6 | | | Camazotz - A planet where people are all equal and exactly alike. |
| | | | Central Intelligence - The most oriented city in Planet Camazotz. |
| 7 | Red | Eyes | The man with red eyes. Prime coordinator. Mystery man in Central. |
| | | | IT - A large brain with a dark mind. Took Charles. |
| | Mr. | Murry | Meg's father. Trapped at Camazotz. |
| 11 | Aunt | Beast | The beast who carried Meg to the Dark Planet. aka: Tall Beast. |
