| Maurice | Abravanel | American classical music conductor. |
| Duane | Allman | Butch's friend. |
| Silvano | Arieti | A psychiatrist. |
| George | Balanchine | An American ballet choreographer. |
| Lucille | Ball | An American actress, comedian. |
| Gregory | Bateson | An anthropologist. |
| Henry Ward | Beecher | An American Congregationalist clergyman. |
| Ivan | Bennett | A psychiatrist. |
| Bruno | Bettelheim | An Austrian-born psychologist. |
| J. Michael | Bishop | An American immunologist and microbiologist. |
| John | Blayney | Billy's husband. |
| Thomas Lindsey | Blayney | Mimi's paternal grandfather. |
| Eugen | Bleuler | A Swiss psychiatrist. |
| Marlon | Brando | American actor. |
| George W. | Bush | 43rd U.S. President. |
| Arvid | Carlsson | A Swedish neuropharmacologist. |
| Carlos | Castaneda | An American author. |
| Dick | Cavett | An American television personality. |
| Marc | Chagall | A Russian-French artist. |
| Charlie | Chaplin | An English comic actor, filmmaker, and composer. |
| Jeff | Cheney | A caregiver. |
| Frédéric | Chopin | A Polish composer and virtuoso pianist. |
| Eric | Clapton | An English rock and blues guitarist, singer, and songwriter. |
| John | Clausen | Worked at the National Institute of Mental Health. |
| Honie B. | Crandall | A psychiatrist. |
| Rue L. | Cromwell | A schizophrenia researcher. |
| Jacques | d'Amboise | An American ballet dancer. |
| Alexandra | Danilova | A Russian-born prima ballerina. |
| Olivia | de Havilland | A British-American actress. |
| Willem | de Kooning | A Dutch-American abstract expressionist artist. |
| Oscar | de la Renta | A Dominican fashion designer. |
| Agnes | de Mille | American dancer and choreographer. |
| James | Dean | American actor. |
| Gilles | Deleuze | A French philosopher. |
| Charles | DeLisi | Lynn DeLisi's husband. |
| Lynn | DeLisi | An American psychiatrist known for her research on schizophrenia. |
| Simone | Dinnerstein | An American classical pianist. |
| Thomas | Eagleton | Former United States Senator from Missouri. |
| Clint | Eastwood | An American actor, film director, composer, and producer. |
| Dwight Davidd | Eisenhower | 34th U.S. President. |
| Marshall | Field | American entrepreneur. |
| Carrie | Fisher | An American actress and writer. |
| Paul Emil | Flechsig | Daniel Paul Schreber's doctor. |
| Michel | Foucault | The French social theorist and countercultural icon. |
| Robert | Freedman | One of the researchers who were investigating schizophrenia. |
| Sigmund | Freud | Austrian neurologist. |
| Robert | Freudenstein | A priest. aka: Freudy. |
| Dr. | Fried | A therapist. |
| Samuel | Fuller | American screenwriter, novelist, and film director. |
| Thomas | Gainsborough | English portrait and a landscape painter and printmaker. |
| Don | Galvin | Mary's father. |
| Donald Kenyon | Galvin | Mimi and Don Galvin's first child. |
| George | Galvin | One of Don's brothers. |
| Mary | Galvin | Don's mother. |
| Mary Christine | Galvin | The youngest daughter of Mimi and Don Galvin. |
| Judy | Garland | American actress, singer, vaudevillian and dancer. |
| Samuel | Gary | The Galvin's new friend. aka: Sam. |
| Ina May | Gaskin | Stephen Gaskin's wife. |
| Stephen | Gaskin | A Marine veteran. |
| Henry | Genain | The father of the quadruplets. |
| Elliot | Gershon | A schizophrenia researcher at NIMH. |
| Alberto | Giacometti | A Swiss sculptor, painter, draftsman and printmaker. |
| Kahlil | Gibran | A Lebanese-American writer. |
| Erving | Goffman | A sociologist. |
| Patricia | Goldman-Rakic | A brain researcher. |
| Matt | Goodwin | One of Peter's doctor. |
| Irving | Gottesman | A psychiatrist. |
| Joanne | Greenberg | Fromm-Reichmann's patient. |
| Eleanor | Griffith | Mimi's friend. |
| Félix | Guattari | A French psychotherapist. |
| Zach | Hall | The chief of NIH's neurological disorders division. |
| Hubert | Harmon | The commander-in-charge of the U.S. Air Force Academy. |
| Mary | Hartnett | Margaret's therapist. |
| Jimi | Hendrix | An American musician, singer, and songwriter. |
| John | Hinckley Jr. | An American criminal. |
| Alfred | Hitchcock | An English film director, producer, and screenwriter. |
| Vladimir | Horowitz | A classical pianist and composer. |
| Tim | Howard | Sam and Nancy Gary's nephew. |
| Carolyn | Howe | One of the founders of the National Alliance for the Mentally Ill. |
| Jim | Howe | One of the founders of the National Alliance for the Mentally Ill. |
| Howard | Hughes | Billy's classmate. |
| Peter | Hurd | American painter. |
| Steven | Hyman | The Director of the Stanley Center for Psychiatric Research. |
| Yaqui | Indian | A boxer. |
| Thomas R. | Insel | An American neuroscientist and psychiatrist. |
| Burl | Ives | American singer. |
| Carl | Jung | A Swiss therapist. |
| Frida | Kahlo | A Mexican painter. |
| Otto | Kahn | A philanthropist. |
| Franz Josef | Kallman | Rudin's student. |
| Kenneth | Kendler | An American psychiatrist. |
| John F. | Kennedy | 35th U.S. President. |
| Howard Pullman | Kenyon | Mimi's grandfather. |
| Ken | Kesey | An American novelist. |
| Seymour | Kety | NIMH's director of research. |
| Genghis | Khan | Founder and first Great Khan and Emperor of the Mongol Empire. |
| Martin Luther | King, Jr. | An American Baptist minister and activist. |
| Monsignor | Kipp | Freudy's boss. |
| Melvin | Kohn | Worked at the National Institute of Mental Health. |
| Emil | Kraepelin | A German psychiatrist. |
| Henry | Laborit | A French surgeon. |
| Jacques | Lacan | A French psychoanalyst. |
| R. D. | Laing | A Scottish psychiatrist. |
| Reed | Larsen | A clinical psychologist for the Air Force Academy Hospital. |
| Jeffrey | Leiberman | The chief psychiatrist of Columbia University Medical Center. |
| Jay | Lichter | Sequana's director of genetics. |
| Theodore | Lidz | A Yale psychiatrist and pioneer in the study of family dynamics. |
| Theodore | Litz | A Yale psychiatrist. |
| Kenny | Loggins | An American singer-songwriter and guitarist. |
| Rachel | Maddow | An American television program host. |
| Maxwell | Maltz | American cosmetic surgeon. |
| Léonide | Massine | A Russian choreographer and ballet dancer. |
| W. F. | McAuley | A British psychiatrist. |
| Paul | McCartney | An English singer, songwriter, musician. |
| Paul | McCartney | An English singer, songwriter. |
| Stefan | McDonough | A neurobiologist. |
| Thomas | McGlashan | A therapist. |
| George | McGovern | An American politician. |
| John | McGrath | An epidemiologist. |
| Margaret | Mead | Gregory Bateson's wife. |
| Linda | Meyer | A ballerina from San Francico Ballet. |
| Kevin | Mitchell | A geneticist. |
| Amedeo | Modigliani | An Italian Jewish painter and sculptor. |
| Thelonious | Monk | An American jazz pianist and composer. |
| Marilyn | Monroe | American actress, model, and singer. |
| Bob | Moorman | The organ player and lead singer. |
| Thomas | Moorman | The superintendent of the ir Force Academy. |
| W. Amadeus | Mozart | A prolific and influential composer of the Classical period. |
| John | Nash | An American mathematician. |
| Louise | Nemser | A psychiatrist. |
| John Jacob | Niles | American composer |
| Richard | Nixon | 37th U.S. President. |
| Richard | Nixon | 37th U.S. President. |
| Jacques | Offenbach | German-born French composer. |
| Georgia | O'Keeffe | American artist. |
| Gordon | Parker | An Australian psychiatrist. |
| Tom | Patterson | A psychiatrist. |
| Carl | Pfeiffer | A pharmacologist. |
| Pablo | Picasso | A Spanish painter, sculptor, printmaker. |
| Zebulon | Pike | An American brigadier general and explorer. |
| Kriss | Prado | Manager at the facility at Pueblo hospital. |
| Ronald | Reagan | 40th U.S. President. |
| Pedro | Real | Argentina's ambassador. |
| Frieda Fromm | Reichmann | A psychotherapist. |
| David | Reiss | The chief of the family studies section at NIMH. |
| Suzanne | Richard | A psychologist. |
| Sugar Ray | Robinson | An American professional boxer. |
| David | Rockefeller | American banker. |
| John | Rosen | A philadelphian psychiatrist. |
| David | Rosenthal | A psychologist and researcher at NIMH. |
| Ernst | Rudin | A researcher. |
| Jean-Paul | Sartre | A French philosopher. |
| Kent | Schnurbusch | Renee's relative. |
| Daniel Paul | Schreber | A lawyer. |
| Ben | Scolnick | A painter. |
| Edward | Scolnick | A researcher from the Broad Institute of MIT and Harvard. |
| James | Shields | Gottesman's coauthor. |
| Karel | Shimoff | A ballerina who has performed with the London Festival Ballet. |
| Edward | Shorter | The Toronto-based psychiatric historian. |
| Martti Olavi | Siirala | A Finnish psychiatrist, psychoanalyst and philosopher. |
| Louise | Silvern | Lindsay's therapist. |
| Albert | Singleton | The hospital's medical director. |
| Carolyn | Skarke | Galvin's neighbor. |
| Laurence | Smith | Donald's physician. |
| Lorelei | Smith | Brian's girlfriend. aka: Noni. |
| Bob | Stabler | A zoologist. |
| Annie | Sullivan | A psychotherapist. |
| Thomas | Szasz | An American-Hungarian psychiatrist. |
| Dariel | Telfer | A writer. |
| Henry | Thoreau | An American naturalist, essayist, poet, and philosopher. |
| Carl | Tillman | A Stanford psychiatrist. |
| E. Fuller | Torrey | A psychiatrist. |
| Leon | Trotsky | A Russian Marxist revolutionary, political theorist and politician. |
| Butch | Trucks | Michael's new friend. |
| Harold | Varmus | The director of the National Institutes of Health. |
| Pancho | Villa | Howard Kenyon's friend. |
| Conrad | Waddington | A British developmental biologist, paleontologist, geneticist. |
| Mary Jane | Ward | American novelist. |
| Daniel | Weinberger | Lynn DeLisi's colleague. |
| Oscar | Wilde | Irish poet and playwright. |
| Frederick | Wiseman | American filmmaker, documentarian, and theater director. |
| Richard | Wyatt | A neuropsychiatrist. |
| Henriette | Wyeth | American artist. |
| Dr. Frank | Zimmerman | The Pueblo hospital longtime superintendent. |
| Atholl | | Galvin's family pet. |
| Attila | | The ruler of the Huns. |
| Becky | | Michael's second wife. |
| Betty | | Mimi's sister. |
| Brian | | One of Mary's brothers. |
| Brody | | Matt Galvin's friend. |
| Chris | | Margaret's ex-husband. |
| Clarke | | One of Don's brothers. |
| Debbie | | Mimi's housekeeper. |
| Dustin | | Richard's friend. |
| Ellie | | One of Wylie and Margaret's daughters. |
| Gertrude | | The mother of the quadruplets. |
| Henry VI | | King of England from 1422 to 1461 and again from 1470 to 1471. |
| Henry VIII | | Former King of England. |
| Hester | | One of the quadruplets who suffered schizophrenia. |
| Iris | | One of the quadruplets who suffered schizophrenia. |
| Jack | | Rick and Lindsay's son. |
| Jean | | Donald's wife. |
| Jim | | One of Mary's brothers. |
| Jimmy | | Jim and Kathy's wife. |
| Joanna of Bourbon | | Queen of France by marriage to King Charles V. |
| John | | One of Mary's brothers. |
| Joseph | | One of Mary's brothers. aka: Joe. |
| Kate | | Rick and Lindsay's daughter. |
| Kathy | | Jim's wife. |
| Katie | | The laundress. |
| King Saud | | King of Saudi Arabia. |
| King Saul | | The first king of the United Kingdom of Israel. |
| Lindsay | | New name of Mary Galvin. |
| Margaret Elizabeth | | Mary's sister. |
| Marilee | | Donald's girlfriend. |
| Mark | | One of Mary's brothers. |
| Mary Queen | | Former Queen of Scotland. |
| Matthew | | One of Mary's brothers. aka: Matt. |
| Michael | | One of Mary's brothers. |
| Mimi | | Mary's mother. |
| Myra | | One of the quadruplets who suffered schizophrenia. |
| Nancy | | Sam's wife. |
| Nancy | | John's new girlfriend. |
| Nancy | | John's wife. |
| Nora | | One of the quadruplets who suffered schizophrenia. |
| Peter | | One of Mary's brothers. |
| Renee | | Richard's girlfriend. |
| Richard | | One of Mary's brothers. |
| Rick | | Lindsay's husband. |
| Rosemary | | Kennedy's eldest sister. |
| Sally | | One of Wylie and Margaret's daughters. |
| Suzy | | One of Sam and Nancy's children. |
| Tina | | One of Sam and Nancy's children. |
| Trudy | | A housekeeper. |
| Wilhelmina | | Mimi's mother. aka: Billy. |
| Wylie | | Margaret's second husband. |
