| | | Part 1 |
| Carl | Sandburg | An American poet. |
| Anna | Fitzgerald | Protagonist. Aka: Anna, Jane Doe. |
| Jesse | Fitzgerald | Anna's older borther. |
| Sedona | | The new girl in Anna's school. |
| Katherine | Fitzgerald | Anna's dying sister. Anna's siamese twin. Aka: Kate. |
| Campbell | Alexander | The lawyer Anna asked help from. |
| Kerri | Donatelli | Campbell's secretary. |
| Dylan | Jerome | Campbell's former client. |
| Sara | Fitzgerald | Anna's mother. |
| Brian | Fitzgerald | Sara's husband. Anna's father. |
| Suzanne | Crofton | Sara's sister. Aka: Zanne. |
| Dr. | Wayne | Kate's doctor. |
| Dr. | Farquad | One of Kate's doctors. |
| Don | Thurman | Brian's former classmate. |
| Lucy | Thurman | Don's wife. |
| | | Part 2 |
| Paulie | | Brian's workmate. |
| Caesar | | Brian's workmate. |
| Red | | Brian's workmate. |
| Dr. Harrison | Chance | One of Kate's doctors. The oncologist. |
| Mrs. | Toohey | Anna's teacher. |
| | | Part 3 |
| Judge | | Campbell's dog. |
| Ophelia | | A waitress Campbell's flirting with. |
| Vern | Stackhouse | The sheriff. |
| Judge | DeSalvo | The Judge at Anna's trial. |
| Dena | DeSalvo | Judge DeSalvo's daughter. Deceased. |
| Mr. | Ollincott | Anna's social studies teacher. |
| Kyle | Mcfee | Anna's friend. |
| Duracell | Dan | A homeless man. A vietnam veteran. |
| Dr. | Nguyen | One of Kate's doctors. |
| | | Part 4 |
| Nadya | Carter | A news reporter. |
| Donna | | An oncology nurse. |
| Julia | Romano | Anna's guard ad litem. Campbell's lover. Aka: Jewel. |
| Isobel | Romano | Julia's sister. Aka: Izzy. |
| Sylvia | | Julia's oven. |
| Smilia | | Julia's fridge. |
| Janet | | Izzy's ex-lover. |
| Trixie | | A polar bear at the zoo. |
| Norton | | A polar bear at the zoo. |
| Kobe | | Trixie's cub. |
| Ernie | Fishkiller | Campbell's client. |
| Tommy | Boudreaux | An ice hockey player at Detroit Redwings. |
| | | Part 5 |
| Jimmy | Stredboe | Anna's schoolmate. |
| Orphan | Annie | Jimmy's rat. |
| Seven | | The bartender Julia met. |
| | | Part 6 |
| Hercules | | Kate's goldfish. |
| Ethan | | Anna's friend. |
| Mittie | | Mallory's mother. |
| Mallory | | Anna's friend. |
| Martha | Stewart | An American executive. |
| | | Part 7 |
| Eldie | Briggs | An 87-year-old woman that Brian rescued. |
| Dr. Peter | Bergen | Chairman of the medical ethics board at Providence Hospital. |
| Luigi | Ravioli | Julia's uncle. |
| Judge | Newbell | A judge. Owner of the car that Jesse stole. |
| Bruce | | The prosecutor. |
| | | Part 8 |
| Mr. | Hume | Anna's science teacher. |
| Anthony | | Julia's brother. |
| Alejandro | | The infant who survives the longest fall. |
| Roy | Sullivan | A man who survived the 7 lightning strike. |
| Mrs. | Zegna | Owner of the burned house. |
| Madame | Agnes | The Fitzgeralds's neighbor with cataract eyes. |
| | | Part 9 |
| Steph | | The nurse who gave Kate her first induction of arsenic. |
| Sarah | Tenting | The ice hockey goalie on team USA. |
| Coach | Ulricht | The ice hockey coach. |
| | | Part 10 |
| Taylor | Ambrose | Kate's fellow cancer patient. |
| Jenna | Ambrose | Taylor's mother. |
| | | Part 11 |
| Dr. | Beata-Neaux | A child psychiatrist. |
| | | Part 12 |
| Stephen | Scarpinio | Anna's classmate. |
| Mrs. | Cuthbert | Anna's teacher. |
| Darren | Hong | Anna's classmate. |
| Oriana | Bertheim | Anna's classmate. |
| | | Part 13 |
| Aretha | Franklin | A cabinet member. |