| | | | Part 1 |
| | Carl | Sandburg | An American poet. |
| | Anna | Fitzgerald | Protagonist. Aka: Anna, Jane Doe. |
| | Jesse | Fitzgerald | Anna's older borther. |
| | Sedona | | The new girl in Anna's school. |
| | Katherine | Fitzgerald | Anna's dying sister. Anna's siamese twin. Aka: Kate. |
| | Campbell | Alexander | The lawyer Anna asked help from. |
| | Kerri | Donatelli | Campbell's secretary. |
| | Dylan | Jerome | Campbell's former client. |
| | Sara | Fitzgerald | Anna's mother. |
| | Brian | Fitzgerald | Sara's husband. Anna's father. |
| | Suzanne | Crofton | Sara's sister. Aka: Zanne. |
| | Dr. | Wayne | Kate's doctor. |
| | Dr. | Farquad | One of Kate's doctors. |
| | Don | Thurman | Brian's former classmate. |
| | Lucy | Thurman | Don's wife. |
| | | | Part 2 |
| | Paulie | | Brian's workmate. |
| | Caesar | | Brian's workmate. |
| | Red | | Brian's workmate. |
| | Dr. Harrison | Chance | One of Kate's doctors. The oncologist. |
| | Mrs. | Toohey | Anna's teacher. |
| | | | Part 3 |
| | Judge | | Campbell's dog. |
| | Ophelia | | A waitress Campbell's flirting with. |
| | Vern | Stackhouse | The sheriff. |
| | Judge | DeSalvo | The Judge at Anna's trial. |
| | Dena | DeSalvo | Judge DeSalvo's daughter. Deceased. |
| | Mr. | Ollincott | Anna's social studies teacher. |
| | Kyle | Mcfee | Anna's friend. |
| | Duracell | Dan | A homeless man. A vietnam veteran. |
| | Dr. | Nguyen | One of Kate's doctors. |
| | | | Part 4 |
| | Nadya | Carter | A news reporter. |
| | Donna | | An oncology nurse. |
| | Julia | Romano | Anna's guard ad litem. Campbell's lover. Aka: Jewel. |
| | Isobel | Romano | Julia's sister. Aka: Izzy. |
| | Sylvia | | Julia's oven. |
| | Smilia | | Julia's fridge. |
| | Janet | | Izzy's ex-lover. |
| | Trixie | | A polar bear at the zoo. |
| | Norton | | A polar bear at the zoo. |
| | Kobe | | Trixie's cub. |
| | Ernie | Fishkiller | Campbell's client. |
| | Tommy | Boudreaux | An ice hockey player at Detroit Redwings. |
| | | | Part 5 |
| | Jimmy | Stredboe | Anna's schoolmate. |
| | Orphan | Annie | Jimmy's rat. |
| | Seven | | The bartender Julia met. |
| | | | Part 6 |
| | Hercules | | Kate's goldfish. |
| | Ethan | | Anna's friend. |
| | Mittie | | Mallory's mother. |
| | Mallory | | Anna's friend. |
| | Martha | Stewart | An American executive. |
| | | | Part 7 |
| | Eldie | Briggs | An 87-year-old woman that Brian rescued. |
| | Dr. Peter | Bergen | Chairman of the medical ethics board at Providence Hospital. |
| | Luigi | Ravioli | Julia's uncle. |
| | Judge | Newbell | A judge. Owner of the car that Jesse stole. |
| | Bruce | | The prosecutor. |
| | | | Part 8 |
| | Mr. | Hume | Anna's science teacher. |
| | Anthony | | Julia's brother. |
| | Alejandro | | The infant who survives the longest fall. |
| | Roy | Sullivan | A man who survived the 7 lightning strike. |
| | Mrs. | Zegna | Owner of the burned house. |
| | Madame | Agnes | The Fitzgeralds's neighbor with cataract eyes. |
| | | | Part 9 |
| | Steph | | The nurse who gave Kate her first induction of arsenic. |
| | Sarah | Tenting | The ice hockey goalie on team USA. |
| | Coach | Ulricht | The ice hockey coach. |
| | | | Part 10 |
| | Taylor | Ambrose | Kate's fellow cancer patient. |
| | Jenna | Ambrose | Taylor's mother. |
| | | | Part 11 |
| | Dr. | Beata-Neaux | A child psychiatrist. |
| | | | Part 12 |
| | Stephen | Scarpinio | Anna's classmate. |
| | Mrs. | Cuthbert | Anna's teacher. |
| | Darren | Hong | Anna's classmate. |
| | Oriana | Bertheim | Anna's classmate. |
| | | | Part 13 |
| | Aretha | Franklin | A cabinet member. |
