| 1 | Aureliano | Buendia Jr. | The colonel. Ursula and Jose Arcadio's son. |
| | Melquiades | | The traveling gypsy responsible for showing the inhabitants of Macondo. |
| | Jose Arcadio | Buendia | The founder of Macondo. Aureliano's brother. |
| | Ursula | Iguaran | Jose's wife. |
| | Aureliano | Buendia Sr. | Jose Arcadio's grandfather. |
| | Jose Arcadio | Buendia Jr. | Jose Arcadio's first-born son. |
| | Francis | Drake | An English Naval officer. A pirate. |
| 2 | Prudencio | Aguilar | Jose's rival. |
| | Pilar | Ternera | Jose Arcadio Jr's wife. |
| | Amaranta | Buendia | Ursula and Jose's daughter. |
| 3 | Arcadio | | Jose Arcadio and Pilar Ternera's son. |
| | Rebeca | | The orphan girl. The girl adopted by the Buendia family. Jose Arcadio's wife. |
| | Nicanor | Ulloa | Rebeca's father. Jose Sr's friend. |
| | Rebeca | Montiel | Rebeca's mother. |
| | Cataure | | The Indian man. |
| | Francisco | The Man | The song composer in Macondo. |
| | Walter | Raleigh | An English writer. |
| | Apolinar | Moscote | The magistrate. |
| | Amparo | Moscote | Apolinar's daughter. |
| | Remedios | Moscote | Apolinar's daughter. Colonel Aureliano's wife. |
| 4 | Pietro | Crespi | An Italian expert. Amaranta and Rebeca's piano tutor. |
| | Aureliano | Jose | Pilar and Colonel Aureliano's son. |
| | Magnifico | Visbal | Aureliano's close friend. |
| | Gerineldo | Marquez | Aureliano's close friend. |
| | Catarino | | A shop owner in Macondo. |
| 5 | Nicanor | Reyna | The priest who performed the wedding ceremony of Aureliano and Remedios. |
| | Alirio | Noguera | Colonel Aureliano's friend. A doctor. |
| | Victorio | Medina | The revolutionary general. |
| | Bruno | Crespi | Pietro's younger brother. |
| | Gregorio | Stevenson | A colonel. |
| | Santa Sofia | De La Piedad | Arcadio's wife. |
| | Roque | Carcinero | The captain. |
| 7 | Jose Arcadio | Segundo | Son of Sofia and Arcadio. |
| | Remedios | The Beauty | Sofia and Arcadio's daughter. |
| | Aureliano | Segundo | Jose Arcadio's twin. |
| | Argenida | | Rebeca's servant. |
| 8 | Visitacion | | Cataure's brother. |
| | Jose Raquel | Moncada | The conservative general. The mayor of Macondo. |
| | Father | Coronel | The new priest at Macondo. Aka: The Pup. |
| | Don Melchor | Escalona | The school head. |
| | Aquiles | Ricardo | The commander of the Garrison. |
| | Carmelita | Montiel | A fortune card teller. |
| 9 | Teofilo | Vargas | A liberal leader. |
| 10 | Fernanda | Del Carpio | Aureliano Segundo's wife. |
| | Jose Arcadio | II | Aureliano and Fernanda's son. |
| | Antonio | Isabel | The successor of the pup. |
| | Petronio | | The sickly sexton. |
| | Petra | Cotes | Aureliano Segundo's concubine. |
| 11 | Renata | Remedios | Fernanda and Aureliano's daughter. Aka: Meme. |
| | Aureliano | Triste | One of Colonel Aureliano's illigitimate sons. |
| | Aureliano | Centeno | Aureliano Triste's brother. |
| 12 | Mr. | Herbert | A hot air balloonist. |
| | Mr. | Brown | A circus performer. |
| 13 | Supreme | Pontiff | The languid apprentice. |
| | Camila | Sagastume | Aureliano Segundo's opponent in the eating contest. |
| 14 | Patricia | Brown | One of Meme's friends. |
| | Mauricio | Babilonia | Meme's lover. |
| 15 | Lorenzo | Gavilan | A colonel in the Mexican Revolution. |
| | Carlos | Cortes-Vargas | The general commander. |
| | Enrique | Garcia-Isaza | The major. Vargas's secretary. |
| 16 | Amaranta | Ursula | Meme's sister. Fernanda and Aureliano Segundo's daughter. |
| 17 | Aureliano | Babilonia | Babilonia and Meme's son. |
| 18 | Aureliano | Amador | One of Colonel Aureliano's
illegitimate sons. |
| 19 | Gaston | | Ursula's husband. |
| | Nigromanta | | Aureliano Babilonia's mistress. |
| | Alvaro | | An Arguer. Aureliano Babilonia's friend. |
| | German | | An Arguer. Aureliano Babilonia's friend. |
| | Alfonso | | An Arguer. Aureliano Babilonia's friend. |
| | Gabriel | | An Arguer. Aureliano Babilonia's friend. |
| 20 | Catalonian | | A bookstore owner in Macondo. |
| | Aureliano III | | The dead child of Amaranta Ursula and Aureliano Segundo. |
