| Lenny | Abrahamson | Director of the Frank film. |
| Terry | Adams | Singer in the band NRBQ. |
| Caroline | Aherne | Chris's brother-in-law's friend. A secretary working at the BBC. |
| Woody | Allen | Managed by Richard. |
| Urban | Avenger | A real-life superhero who chose to remain masked for long periods. |
| Edward | Barton | A quiet, bearded man who would stand onstage and scream. |
| Louis | Black | Daniel's friend. |
| Carla | Bley | Jazz composer. |
| Adam | Buxton | Radio presenter. |
| George | Clooney | Actor. |
| Kurt | Cobain | Nirvana front man. |
| Lloyd | Cole | Songwriter. |
| Mike | Doherty | The guy who called Jon over the phone. Drummer of the band. |
| John | Dowie | Comedian. |
| Chris | Evans | The band's driver. |
| Michael | Fassbender | Stars in the Frank movie. |
| Jeff | Feuerzeig | Created the documentary The Devil and Daniel Johnston. |
| Patrick | Gallagher | The bassist of the band. |
| The Spice | Girls | Managed by Richard. |
| Domhnall | Gleeson | Stars in the Frank movie. |
| Gary | Glitter | An artist Frank supported. |
| Maggie | Gyllenhaal | Stars in the Frank movie. |
| Frank | Hatherley | Jon's old college lecturer. |
| Pee Wee | Herman | A comedic character created by Paul Reubens. |
| Elton | John | Entertainer. 3rd highest paid entertainer Year 2000. |
| Daniel | Johnston | Texas singer-songwriter. |
| Stanley | Kubrick | Director. |
| Lennox | Lewis | Entertainer. 2nd highest paid entertainer Year 2000. |
| Stephen | Mangan | Actor. |
| Mrs. | Meron | Frank's neighbor. Voiced by Caroline. |
| Paul | Merton | Comedian. |
| Mike | Middles | Music journalist. |
| Kylie | Minogue | Singer. |
| Susan | Orlean | Journalist. |
| The | Pixies | Managed by Richard. |
| Bonnie | Raitt | American singer. |
| Jonathan | Richman | An artist Frank and Jon supported. |
| Rick | Sarko | The guitarist of the band. |
| Rick | Senat | Stanley's old business affairs manager. |
| George Bernard | Shaw | Wrote The Unreasonable Man. |
| Frank | Sidebottom | The band's front man. AKA: Chris. |
| Peter | Straughan | The film writer of The Men Who Stare at Goats. |
| Janet | Street-Porter | From BBC. |
| Neil | Taylor | A Timperley village councillor. |
| Mark | Thomas | Comedian. |
| Midge | Ure | The lead singer of the band Ultravox. |
| Don Van | Vliet | Ruled over his band with a tyrannical fury. AKA: Captain BeefHeart. |
| Betty | Wiggin | A singer in the band The Shaggs. |
| Dot | Wiggin | A singer in the band The Shaggs. |
| Austin | | Dot and Betty's father. |
| Bert | | Caroline's father. |
| Bill | | Daniel's father. |
| Bob | | An amicable cat Mike was living with. |
| Fred | | Dot's then-husband. |
| Mabel | | Daniel's mother. |
| Mani | | Jon's next-door neighbor. Part of the band Stone Roses. |
| Maureen | | Caroline's mother. |
| Nico | | Moved into Hulme from the Velvet Underground. |
| Paula | | Chris's former wife. |
| Richard | | Guitarist of the Desert Wolves. One of the most successful tour managers. |
| Shep | | A man in Highbury. |
| Sterling | | Chris's son. |