| Charles | Aule | Teddy's new partner. AKA: Chuck. |
| Dr. | Axelrod | A psychologist. |
| Fred | Baker | The kid that Teddy helped. |
| Peter | Breene | One of the patients. |
| Dr. | Brotigan | The neurosurgeon. |
| John | Cawley | The institution's chief of staff. |
| Margaret | Cawley | Dr. Cawley's wife. AKA: Peggy. |
| Dolores | Chanal | Teddy's wife. Deceased. AKA: Linda Cox. |
| Nikos | Costa | The boat owner. |
| Edward | Daniels | Protagonist. A U.S. Marshall. AKA: Teddy. |
| Bobby | Farris | The warden at Renton. |
| Ken | Gage | One of the patients. |
| Mr. | Ganton | The head of orderly. |
| Frankie | Gordon | Another sergeant from Intel. |
| Leonora | Grant | One of the patients. |
| Vincent | Gryce | A patient who kills all of his relatives. |
| Bridget | Kaerns | The patient who killed his own husband. |
| Andrew | Laeddis | The mystery patient. |
| Daniel | Laeddis | Andrew's son. Deceased. |
| Edward | Laeddis | Andrew's son. Deceased. |
| Rachel | Laeddis | Andrew's daughter. Deceased. |
| Bibby | Luce | Trey's roommate. |
| Kerry | Marino | One of the nurses. |
| Glen | Miga | One of the orderlies. |
| Maggie | Moonpie | The patient who has a scar in her throat. |
| Jeremiah | Naehring | Dr. Cawley's colleague. |
| George | Noyce | The patient that Teddy beat. |
| Gil | Restak | A fisherman. |
| Lester | Sheehan | The head of the therapy session. |
| James | Solando | Rachel's husband. AKA: Jim. |
| Rachel | Solando | The missing patient. |
| Colonel | Spivey | The owner of the "Great Room". |
| Julie | Taketomi | Chuck's wife. |
| Arthur | Toomey | One of the patients. |
| Tootie | Vicelli | The soldier that Teddy served with in the army. |
| Paul | Vingis | The patient who killed his brother's wife and kids. |
| Dorish | Walsh | The first test patient. |
| Trey | Washington | One of the orderlies. |
| Mr. | Willis | The institution's admin. |
| Al | | One of Dr. Cawley's men. |
| Ben | | One of the orderlies. |
| Byron | | One of the wardens. |
| Emily | | A nurse. |
| Harry | | The institution's facilitator. |
| Hurly | | The senator. |
| Litchfield | | One of the patients. |
| Marie | | Cawley's ex-lover. |
| Mcpherson | | A deputy warden. |
| Willy | | One of the patients. |
