| Mary | Bailey | Miss Smith's assistant. |
| Isaac | Baker-Brown | Senior surgeon at London Surgical Home. |
| Isaac | Blessing | Rebecca's husband. |
| Rebeca | Blessing | Elizabeth's friend. |
| Thomas | Bonfield | One of Theophilus' lawyers. |
| Lizzie | Bonner | The patient beater. |
| Emeline | Bridgman | Elizabeth's special friend. |
| William | Brown | The chairman. |
| Mrs. | Celia | The asylum's cook. |
| Maria | Chapman | Elizabeth's new friend. |
| Betsy | Clarke | Elizabeth's new friend |
| Celia | Coe | One of the asylum's attendants. |
| James | Coe | The asylum's cook. |
| Mr. | Comstock | Isaac's boss. |
| James | Cowles-Prichard | An Englishman. |
| Mrs. | De La Hay | The asylum's attendant. |
| Dorothea | Dix | A mental health campaigner. |
| Deacon | Dole | Sybil's husband. |
| Sybil | Dole | Theophilus' sister. |
| Alexander | Duncasson | One of Elizabeth's witnesses. |
| Angeline | Field | Elizabeth's cousin. |
| David | Field | Angeline's husband. |
| Allen | Fuller | The General. |
| Emily | Goldsby | The epelectic woman. |
| Mrs. | Grere | One of the patients. |
| Caroline Ann | Haslett | Elizabeth's friend. AKA: Sarah. |
| William | Haslett | The town supervisor. |
| Jenny | Haslety | One of the patients. |
| Mrs. | Hosmer | The sewing room directress. |
| Christopher | Knott | The doctor who signed Elizabeth's insanity certificate. |
| Chauncey | Lake | One of Theophilus' lawyers. |
| Mason | Loomuis | Theophilus' lawyer. |
| Harrison | Loring | Moore's assistant. |
| Sallie | Low | One of the patients. |
| James | Mann | A Manteno physician. |
| Cyrus | McCormick | One of America's richest men. |
| Andrew | McFarland | The asylum's superintendent. |
| Lemuel | Milk | One of the juries. |
| Ira | Minard | Sarah's husband. A real estate mogul. |
| Sarah | Minard | Elizabeth's close compatriot. |
| Steve | Moore | Elizabeth's lawyer. |
| Daniel | Needy | Former Manteno supervisor. |
| Dr. | Newkirk | Members of Theophilus' church. |
| Richard | Oglesby | The Governor. |
| Sophia | Olsen | Elizabeth's biggest fan. |
| James | Orr | Moore's assistant. |
| Arthur | Packard | Elizabeth's son. |
| Elizabeth | Packard | Protagonist. |
| George | Packard | Elizabeth's son. |
| Isaac | Packard | Elizabeth's son. AKA: Toffy. |
| Libby | Packard | Elizabeth's daughter. |
| Samuel | Packard | Elizabeth's son. |
| Theophilus | Packard | Elizabeth's husband. |
| Sarah | Rumsey | The Packard's new maid. |
| Hervey | Severance | Theophilus' brother-in-law. |
| Marian | Severance | Theophilus' sister. |
| Tirzah | Shedd | Elizabeth's witness. |
| Dr. | Shirley | The Blessing's psychiatrist. |
| Isaac | Simington | The Methodist minister. |
| Miss | Smith | The new head of Eight Ward. |
| Elizabeth Cady | Stanton | A women's rights campaigner. |
| Charles | Starr | The judge. |
| Sarah | Triplet | The most dangerous patient in the women's ward. |
| Samuel | Ware | Elizabeth's father. |
| Joseph | Way | A psychologist from Kankakee. |
| Miss | Weaver | One of the patients. |
| JOseph | Younglove | One of Elizabeth's friends. |
| Merrick | | Members of Theophilus' church. |
| Spring | | The deacon in Theophilus' church. |
| Tenny | | The asylum's assistant physician. |