| | | The House On A Mango Street. |
| Carlos | Cordero | Esperanza's brother. |
| Mrs. E. | Cordero | Esperanza's mother. aka: Mama. |
| Mr . | Cordero | Esperanza's father. aka: Papa. |
| Kiki | Cordero | Esperanza's youngest brother. |
| Magdalena | Cordero | Esperanza's sister. aka: Nenny. |
| Esperanza | Cordero | The protagonist and narrator. |
| Joe | | The baby grabber. |
| Mr. | Benny | The grocery store owner. |
| Blanca | | Mr. Benny's wife. |
| Edna | | Owner of the building next to Esperanza's house. |
| Alicia | | Esperanza's former friend. |
| Cathy | | Esperanza's neighbor. |
| Lucy | Guerrero | Esperanza's new friend. |
| Rachel | | Lucy's sister. |
| Juan | Ortiz | A man who moved to Cathy's house. aka: Meme. |
| Louie | | Carlos's Puerto Rican friend. |
| Marin | | Louie's cousin. |
| Rosa | Vargas | A single mother. Esperanza's neighbor. |
| Efren | Vargas | Rosa Vargas's son. |
| Angel | Vargas | Rosa Vargas's daughter. |
| Darius | | Doesn't like school. |
| Tito | | Sells bikes. |
| Mildred | | Rachel's cousin. |
| Joey | | Rachel's cousin. |
| Nereida | | Rachel's cousin. |
| Marco | | Rachel's cousin. |
| Sue | | Rachel's cousin. |
| Gloria | | Nenny's best friend. |
| Nacho | | Esperanza's uncle. |
| Lala | | Esperanza's aunt. |
| Guadalupe | | Esperanza's aunt. aka: Lupe. |
| Elenita | | An alleged witch. Esperanza's neighbor. |
| Geraldo | | A man Marin met at the Dance Party. |
| Ruthie | | Edna's daughter. |
| Bobo | | Ruthie's dog. |
| Earl | | A man who lives next-door to Edna's basement. |
| Sire | | Lois's boyfriend. |
| Lois | | Sire's girlfriend. |
| Mamacita | | A big fat mother. Esperanza's neighbor. |
| Rafaela | | A young mother. Esperanza's neighbor. |
| Sally | | Esperanza's beautiful neighbor. |
| Cheryl | | Sally's friend. |
| Minerva | | Esperanza's neighbor. |
| Eddie | Vargas | Rosa Vargas's son. |