| | | | The House On A Mango Street. |
| | Carlos | Cordero | Esperanza's brother. |
| | Mrs. E. | Cordero | Esperanza's mother. aka: Mama. |
| | Mr . | Cordero | Esperanza's father. aka: Papa. |
| | Kiki | Cordero | Esperanza's youngest brother. |
| | Magdalena | Cordero | Esperanza's sister. aka: Nenny. |
| | Esperanza | Cordero | The protagonist and narrator. |
| | Joe | | The baby grabber. |
| | Mr. | Benny | The grocery store owner. |
| | Blanca | | Mr. Benny's wife. |
| | Edna | | Owner of the building next to Esperanza's house. |
| | Alicia | | Esperanza's former friend. |
| | Cathy | | Esperanza's neighbor. |
| | Lucy | Guerrero | Esperanza's new friend. |
| | Rachel | | Lucy's sister. |
| | Juan | Ortiz | A man who moved to Cathy's house. aka: Meme. |
| | Louie | | Carlos's Puerto Rican friend. |
| | Marin | | Louie's cousin. |
| | Rosa | Vargas | A single mother. Esperanza's neighbor. |
| | Efren | Vargas | Rosa Vargas's son. |
| | Angel | Vargas | Rosa Vargas's daughter. |
| | Darius | | Doesn't like school. |
| | Tito | | Sells bikes. |
| | Mildred | | Rachel's cousin. |
| | Joey | | Rachel's cousin. |
| | Nereida | | Rachel's cousin. |
| | Marco | | Rachel's cousin. |
| | Sue | | Rachel's cousin. |
| | Gloria | | Nenny's best friend. |
| | Nacho | | Esperanza's uncle. |
| | Lala | | Esperanza's aunt. |
| | Guadalupe | | Esperanza's aunt. aka: Lupe. |
| | Elenita | | An alleged witch. Esperanza's neighbor. |
| | Geraldo | | A man Marin met at the Dance Party. |
| | Ruthie | | Edna's daughter. |
| | Bobo | | Ruthie's dog. |
| | Earl | | A man who lives next-door to Edna's basement. |
| | Sire | | Lois's boyfriend. |
| | Lois | | Sire's girlfriend. |
| | Mamacita | | A big fat mother. Esperanza's neighbor. |
| | Rafaela | | A young mother. Esperanza's neighbor. |
| | Sally | | Esperanza's beautiful neighbor. |
| | Cheryl | | Sally's friend. |
| | Minerva | | Esperanza's neighbor. |
| | Eddie | Vargas | Rosa Vargas's son. |
