| Leonello | Baldassare | Alfonso's good friend and adviser. |
| Ercole | Contrari | The head of the guardsmen. |
| Renee | de France | Alfonso's mother. |
| Lucrezia | de' Medici | Duchess of Ferrara. aka: Lucre. |
| Alfonso II | d'Este | Duke of Ferrara. |
| Sebastiano | Filippi | An Italian painter. aka: II Bastianino. |
| Paolo Giordano | Orsini | Isabella's fiancé. |
| Torquato | Tasso | An Italian poet. |
| Giorgio | Vasari | An Italian painter, architect, writer and historian. |
| Achilles | | A hero of the Trojan War. |
| Agamemnon | | A king of Mycenae. |
| Anna | | One of Alfonso's sisters. |
| Bronzino | | An Italian Mannerist painter. |
| Clelia | | One of Lucrezia's maid. |
| Cosimo I | | Grand Duke of Tuscany. |
| Dianora | | Pietro's wife to be. |
| Eleonora | | Cosimo's wife. |
| Elisabetta | | Alfonso's sister. aka: Elisa. |
| Emilia | | One of Lucrezia's maid. |
| Ferdinando | | One of Lucrezia's brothers. |
| Francesco | | One of Lucrezia's brothers. |
| Garzia | | One of Lucrezia's brothers. |
| Giovanni | | One of Lucrezia's brothers. |
| Helen of Sparta | | The most beautiful woman in the world. |
| Henry I | | King of England. |
| Hercules | | A hero of Greek and Roman mythology. |
| Isabella | | One of Lucrezia's sisters. |
| Jacopo | | One of II Bastianino's assistants. |
| Luigi | | Alfonso's brother. |
| Maria | | Lucrezia's sister. |
| Maurizio | | One of II Bastianino's assistants. |
| Menelaus | | A Greek hero. |
| Michelangelo | | An Italian sculptor, painter, architect and poet. |
| Nunciata | | One of Alfonso's sisters. aka: Nuncia. |
| Pietro | | Lucrezia's baby brother. |
| Sofia | | Eleonora's nurse. |
| Vitelli | | Cosimo's adviser. |
| Zeus | | The god of the sky in ancient Greek mythology. |
