| 1 | | | Sadie |
| | Will | Foust | A professor teaching human ecology. |
| | Tate | | One of Will's children. |
| | Otto | | One of Will's children. |
| | Sadie | Foust | A physician. Will's wife. |
| | Imogen | | Will's niece. |
| | Alice | | Will's sister. |
| 2 | | | Sadie |
| | George | Nelson | Will and Sadie's neighbor. |
| | Poppy | | George Nelson's wife. |
| 3 | | | Sadie |
| | Emma | | A receptionist. |
| | Joyce | | Nurses department head. |
| | Mr. | Jansen | Otto's teacher. |
| | Morgan | Baines | Will and Sadie's neighbor. |
| | Dr. | Sanders | Sadie's colleague. |
| 4 | | | Camille |
| | Jack | | One of Sadie's friends. |
| | Emily | | One of Sadie's friends. |
| 5 | | | Sadie |
| | Berg | | A police officer. |
| | Jeffrey | Baines | Morgan's husband. aka: Jeff. |
| | Stephen | Colbert | An American comedian. |
| 7 | | | Sadie |
| | Erin | Sabine | Will's first
fiancé. |
| 8 | | | Mouse |
| | Mouse | | Jeffrey Baines' daughter. |
| | Bear | | Mouse's favorite stuffed toy. |
| 15 | | | Camille |
| | Carrie | Laemmer | Will's student. |
| 17 | | | Sadie |
| | Patty | | Morgan's mother. |
| | Karen | | One of Sadie's new acquaintances. |
| | Susan | | One of Sadie's new acquaintances. |
| | Courtney | | Jeffrey's first wife. |
| 18 | | | Sadie |
| | Jessica | | Mother of Tate's buddy. |
| 19 | | | Sadie |
| | Amanda | | A doctor. |
| 20 | | | Mouse |
| | Bert | | A guinea pig. |
| | Bert | Campanares | A basketball player. |
| 27 | | | Sadie |
| | Amy | | Berg's daughter. |
| 32 | | | Sadie |
| | Elizabeth | | Imogen's half-sister. |
| 38 | | | Mouse |
| | Max | | Fake mom's dog. |
| 39 | | | Sadie |
| | Officer | Bisset | A police officer. |
| | Camille | | Will's other woman. |
| 40 | | | Sadie |
| | Charlotte | Sneider | Sadie's stepmother. |
| 43 | | | Will |
| | Andrea | | Will's colleague. |
| | Samantha | | Will's acquaintance. |
| 53 | | | Sadie |
| | Beverly | | Sadie's therapist. |
| | Bob | | Sadie's family's therapist. |
