| 1 | Esther | Cunningham | Mitford's former mayor. |
| | Timothy | Kavanagh | A retired priest. Aka: Tim. |
| | Dr. | Wilson | Mitford's doctor. |
| | Cynthia | Kavanagh | Tim's wife. |
| | Puny | | Tim and Cynthia's housekeeper. |
| | Truman | | Tim's cat. |
| | Adele | Hogan | The Mitford's police captain. J.C.'s wife. |
| | Vanita | Bentley | A Mitford writer. |
| | J.C | Hogan | The editor of Mitford Muse. |
| | Coot | Hendrick | The Mitford's town fixture. |
| | Grace | Murphy | A Mitford's teacher. |
| | Sister | Louise | Grace's aunt. |
| | Esther | Bolick | A retired baker. |
| | Samantha | | Esther's friend. |
| | Avis | Packard | A grocery store owner. |
| | Irene | McGraw | One of Avis's customers. Lace's friend. |
| | Winnie Ivey | Kendall | A bakery shop owner. |
| | Ray | Cunningham | Esther's husband. |
| | Lew | Boyd | A mechanic shop owner. |
| | Earlene | Boyd | Lew's wife. |
| | Dooley | Kavanagh | Tim's adopted son. The owner of Kavanagh's clinic. |
| | Lace | Turner | Dooley's wife. A painter. |
| | Dora | Pugh | A hardware store owner. |
| | Jack | Tyler | Dooley's adopted son. |
| | Hope | Murphy | Grace's sister. The owner of Hope's House. |
| 2 | Charley | | Dooley's golden retriever. |
| | Willie | | The Meadowgate's farmhand. |
| | Harley | Welch | One of Dooley's workers. |
| | Hal | Owen | Dooley's mentor. Aka: Doc Owen. |
| | Blake | Eddistoe | Hal's long-time vet tech. |
| | Amanda | | Hal's long-time receptionist. |
| | Joanna | Rivers | A veterinarian. |
| | Harold | Odom | Hobie's owner. |
| | Hobie | | Harold's terrier. One of Dooley's patients. |
| | Helene | Pringle | The French piano teacher. |
| | Lily | Flower | Dooley and Lace's housekeeper. |
| | Chester | | One of Dooley's patients. |
| | Kim | Dorsay | Irene's sister. Lace's friend. |
| | Marge | Owen | Hal's wife. |
| | Pete | | Jack's bulldog. |
| | Hoppy | | Lace's adoptive father. Aka: Grandpa Hoppy. |
| | Olivia | | Lace's adoptive mother. Aka: Grandma O. |
| | Sadie | Baxter | Louella's adopted daughter. Aka: Miss Sadie. |
| | Bartlett | | Miss Sadie's trust officer. |
| 3 | Andrew | Gregory | The current mayor. |
| | Joe Joe | Guthrie | The Mitford Police Chief. Puny's husband. |
| | Wanda | Bassinger | A café owner. |
| | Lois | Burton | The manager at the woolen shop. |
| | Father | Brad | A priest. |
| | Percy | Mosely | A traveler. |
| | Velma | Mosely | Percy's wife. |
| | Mary Ellen | Middleton | Beth's mother. Father Brad's lover. |
| | Lilah | | The committee head. |
| | Emma | Newland | Tim's former church secretary. |
| | Harold | Newland | Emma's husband. |
| | Abe | Edelman | Tim's friend. |
| 4 | Beth | Middleton | Lace's best friend. Mary Ellen's daughter. |
| | Pooh | Barlowe | Jack's uncle. Dooley's brother. |
| | Tommy | | Dooley's best friend. |
| | Rebecca Jane | Owen | Hal's daughter. |
| 5 | Henry | Winchester | Tim's brother. |
| | Kenny | Barlowe | Dooley's brother. |
| | Leslie | | Grace's best friend. |
| | Sarah | | Grace's best friend. |
| 6 | Sammy | Barlowe | Dooley's brother. |
| 7 | Shirlene | Hatfield | A spray-tan booth owner. |
| | Omer | Cunningham | Avis's wife. |
| | Pete (2) | | A retired handyman service. |
| | Margaret | | Esther Bolick's aunt. |
| | Gene | Bolick | Esther's husband. |
| | Otis | James | Avis's long-time worker. |
| | Lisa | James | Otis's wife. |
| | Marjorie | Douglas | One of Avis's regular customers. |
| | Jake | Tulley | A car dealership owner. |
| | Tammy | Tulley | Jake's wife. |
| | Jessie | Barlowe-Leeper | Dooley's sister. |
| | Green | | A local nurse. |
| | Homer | | One of Dooley's patients. |
| | Lucy | Bowman | Dooley's friend. |
| | Teddy | | One of Dooley's dogs. |
| | Nurse | Kennedy | A nurse. |
| 9 | Louella | Baxter-Marshall | A long-time resident of Hope's House. |
| | Shirlene | Cunningham | Omer's wife. |
| | Scott | | Coot's colleague. |
| | Henry | Talbot | Mitford's priest. |
| | Pauline | Barlowe-Leeper | Dooley's mother. |
| | Henry | Barlowe | Dooley's brother. |
| | Buck | Leeper | Pooh's adoptive father. |
| | Chucky | | Avis's dog. |
| | Timmy | Guthrie | Puny and Joe's son. |
| | Tommy | Guthrie | Puny and Joe's son. Timmy's twin. |
| | Sassy | Guthrie | Puny and Joe's daughter. |
| | Sissy | Guthrie | Puny and Joe's daughter. Sassy's twin. |
| 10 | Danny | Hershell | An ex-convict. |
| | Austin | Teague | One of Dooley's clients. |
| | Redeemer | | Austin's hound. Dooley's patient. |
| | Judy | | The postmistress. |
| | Etta | | Julie and Kenny's son. |
| | Ethan | | Julie and Kenny's son. |
| | Mink | Hershell | Mink's wife. Owner of Chips. |
| | Honey | Hershell | Mink's wife. Owner of Chips. |
| | Chips | | Mink and Honey's dog. One of Dooley's patients. |
| 11 | Loretta | | The egg seller. |
| | Margaret | | Grace's cat. |
| | Jay | Barringer | The new owner of Lew's Exxon. |
| | Mule | Skinner | J.C.'s colleague. |
| | Fancy | Skinner | Mule's wife. |
| | Eva | Winchester | Henry's wife. |
| | Lucille | | Eva's sister. |
| 12 | Choo | Choo | Jack's dog. |
| | Frye | Hickman | A hunter. |
| | Artie | Johnson | Janette's husband. |
| | Janette | Johnson | The pregnant woman that Dooley helped. |
| 13 | Clyde Henry | Barlowe | Dooley's biological father. |
| | Marcie | Guthrie | Joe Joe's mother. One of Esther Cunnigham's daughters. |
| 15 | Billie | Pope | Johnsie's brother. |
| | Johnsie | Pope | Avis's friend from the valley. |
| | Pedro | Sanchez | Avis's friend from the valley. |
| | Maria | Sanchez | Pedro's wife. |
| | Hank | Griffin | Avis's friend from the valley. |
| | Donny | Bentley | Vanita's husband. |
| 17 | Hamp | Floyd | The former Mitford fire chief. |
| | Clovis | Baillie | Hamp's go-to
Santa for the Christmas parade. |
| | Harold | Mincer | Dannye's husband. |
| | Dannye Lee | Mincer | Harold's wife. |
| 20 | James Wesley | Barlowe | Julie and Kenny's baby. |
| | Linda | Pope | A doctor at Mitford Hospital. |
| 21 | Brooke | Logan | The woman who confessed to Father Tim. |
| | Blaise | Pascal | A brilliant mathematician. |
| 22 | Ivy Amelia | Anderson | Tommy's grandmother. |
| | Milton | | Tommy's grandfather. |
| | Adrienne | Millhouse | The girl that Tommy loves. |
| | Ned | | The man who works at Fernbank. |
| | Boid | Lewis | The owner of the wagon Sadie and Louella rides. |
| | Lewis | Young | The owner of the wagon Sadie and Louella rides. |
| | Drew | | Father Brad's helper. |
| | Tiffany | | Father Brad's helper. |
