| Pro | Major | Palgrave | Character from Agatha's book. |
| | Agatha | Christie | Mystery novelist. Aka: Mary Miller. |
| | Katharine | Keeling | Commercial artist. Agatha's cabin mate. Aka: Katharine Woolley. |
| | Nancy | Neele | Archie's lover. |
| | Rosalind | | Agatha's daughter. |
| 1 | Archie | Christie | Agatha's ex-husband. |
| | Leonard | Woolley | British archaeologist. Aka: Len. |
| | Charlotte | | Agatha's friend and assistant. |
| | Bertram | Keeling | Katharine's late husband. |
| 2 | Muriel | Harper | Nancy's fake traveling companion. |
| 3 | Eileen | | Agatha's friend. |
| | Reggie | Lucy | Agatha's former fiancée. |
| 4 | Madge | | Agatha's sister. |
| | Hercule | Poirot | Belgian detective in Agatha's books. |
| | Jack | | Agatha's nephew. |
| | Nancy | Nelson | Woman married to Viscount. Aka: Ann Grandfield, Ann Nelson. |
| | Felix | Nelson | Nancy's husband. |
| 5 | Max | Mallowan | One of Woolley's crew. |
| 6 | Delia | Grandfield | Nancy's cousin. |
| | Rowland | | Nancy's uncle. |
| 7 | Tony | | Agatha's nephew. |
| | Signorina | Tedaldi | One of the passengers of the Orient Express. |
| | Miss | Johnston | One of the passengers of the Orient Express. |
| 8 | Esme | Howard | Son of Lord Howard of Penrith. |
| | Jean-Claude | | Katharine's French companion. |
| 9 | John | Lane | Agatha's publisher. |
| | Michael C. | Deacon | Woolley's draftsman. |
| 10 | Amanthi | | Katharine's nanny. |
| 12 | Jim | Nairn | One of the Australian who runs the Taurus Express. |
| 18 | Saleem | | One of Woolley's Arab employees. |
| | Ibrahim | | Woolley's cook. |
| 19 | Hamoudi | | Site foreman. |
| 20 | Duncan | | Archaeologist. Ceramics expert. |
| | Pierre | | Site epigraphist. |
| 24 | Hugh | Carrington | Assistant to the High Commissioner. |
| | Munshid | | Sheikh of the Ghazi. |
| 26 | James |
Frederick | Nancy's son. |
| Epi | Mathew | | Rosalind's son. |
