| Pro | Meritaten | | The Egyptian princess. Daughter of Pharaoh. |
| | Gaythelos | | Meritaten's husband. |
| | Osarseph | | The prophet aided by Meritaten. |
| | Ahrwn | | Osarseph's brother. |
| | | | Part 1 |
| 1 | | | Cerron Grande - The largest reservoir in El Salvador. |
| | Elise | Aguilar | Scientist - Agency for International Development El Salvador. |
| | Rondi | | Salvadoran villager aiding U.S. scientist. Elise's companion. |
| | Mr. | Phillip | A man who helped build a windmill. |
| | Phil | | Elise's colleague. |
| 2 | Dirk | Pitt Sr. | The head of NUMA. Protagonist. |
| | | | NUMA - National Underwater and Marine Agency. |
| | Al | Giordino | Director of NUMA's underwater technology. |
| 8 | Ron | Posey | The captain of the boat called Mayweather. |
| | Gauge | | Ron's second-in-command officer. |
| 9 | Loren | Smith-Pitt | Pitt's wife. A congresswoman. |
| | Rudi | Gunn | The NUMA's deputy director. |
| | Zerri | Pochinski | Pitt's long-time secretary. |
| 10 | Stanton | Bradshaw | The State Senator. Chairman of the senate committee. |
| | Evanna | McKee | The CEO of BioRem Global. Audrey's mother. |
| 11 | Audrey | McKee | The field manager of BioRem Global. Evanna's daughter. |
| | Michael | Cruz | NUMA's marine engineer and salvage expert. |
| 14 | Rachel | | One of Evanna's associates. |
| 15 | Dr. Stephen | Nakamura | An epidemiologist at the University of Maryland. |
| 17 | Ross | | An FBI Agent. Elise's protector. |
| | Susan | Montgomery | The Head of Environmental Health Laboratory in Atlanta. |
| | Miles | Perkins | A scientist at Inverness Research Laboratory. |
| | | | Part 2 |
| 18 | Manjeet | Dhatt | Pratima's husband. The father of the ill boy in Mumbai. |
| Pratima |
Dhatt | Manjeey's wife. The mother of the ill boy in Mumbai. |
| 19 | Rodney | Zeibig | NUMA's marine archaeologist. |
| | Harrison | Stanley | An emeritus professor of Egyptology from Cambridge. |
| | Riki | Sadler | A biochemist and archaeologist. Evanna's daughter. |
| | Frasier | McKee | Evanna's husband. Deceased. |
| | Aziz | | An Egyptian antiquities ministry agent. |
| 20 | Summer | Pitt | Pitt's daughter. NUMA's special projects director. |
| | Dirk | Pitt Jr. | Pitt's son. NUMA's special projects director. |
| 27 | St. Julian | Perlmutter | Pitt's old friend. A historian. |
| 28 | Hiram | Yaeger | NUMA's computer resource center director. |
| 29 | Ozzie | Ackmadan | The proprietor of the Abu Simbel Inn. |
| | | | Part 3 |
| 35 | Byron | | A lab research director. |
| 36 | Richard | | One of Evanna's associates. |
| 38 | Abigail | Brown | Former Prime Minister of Australia. CEO of the World Bank. |
| 39 | Eamon | Brophy | Pitt's friend.
Former archaeology dept. head Dublin University. |
| 40 | Gavin | | One of Evanna's associates. |
| | Ainsley | | One of Evanna's associates. |
| | Irene | | One of Evanna's associates. |
| 43 | Friar | Thomas | The Franciscan Friary of Killarney. |
| 73 | James | Sandecker | The current U.S. Vice President. NUMA's former director. |
