| Ozzie | Ackmadan | The proprietor of the Abu Simbel Inn. |
| Elise | Aguilar | Scientist U.S. Agency for International Development
- El Salvador. |
| Stanton | Bradshaw | The State Senator. Chairman of the senate committee. |
| Eamon | Brophy | Pitt's friend. Archaeology department head
- Dublin University. |
| Abigail | Brown | Former Prime Minister of Australia. CEO of the World Bank. |
| Michael | Cruz | NUMA's marine engineer and salvage expert. |
| Manjeet | Dhatt | Pratima's husband. The father of the ill boy in Mumbai. |
| Pratima | Dhatt | Manjeey's wife. The mother of the ill boy in Mumbai. |
| Al | Giordino | Director of NUMA's underwater technology. |
| Rudi | Gunn | The NUMA's deputy director. |
| Audrey | McKee | The field manager of BioRem Global. Evanna's daughter. |
| Evanna | McKee | The CEO of BioRem Global. Audrey's mother. |
| Frasier | McKee | Evanna's husband. Deceased. |
| Susan | Montgomery | The Head of Environmental Health Laboratory in Atlanta. |
| Dr. Stephen | Nakamura | An epidemiologist at the University of Maryland. |
| Miles | Perkins | A scientist at Inverness Research Laboratory. |
| St. Julian | Perlmutter | Pitt's old friend. A historian. |
| Mr. | Phillip | A man who helped build a windmill. |
| Summer | Pitt | Pitt's daughter. NUMA's special projects director. |
| Dirk | Pitt Jr. | Pitt's son. NUMA's special projects director. |
| Dirk | Pitt Sr. | The head of NUMA. Protagonist. |
| Zerri | Pochinski | Pitt's long-time secretary. |
| Ron | Posey | The captain of the boat called Mayweather. |
| Riki | Sadler | A biochemist and archaeologist. Evanna's daughter. |
| James | Sandecker | The current U.S. Vice President. NUMA's former director. |
| Loren | Smith-Pitt | Pitt's wife. A congresswoman. |
| Harrison | Stanley | An emeritus professor of Egyptology from Cambridge. |
| Friar | Thomas | The Franciscan Friary of Killarney. |
| Hiram | Yaeger | NUMA's computer resource center director. |
| Rodney | Zeibig | NUMA's marine archaeologist. |
| Ahrwn | | Osarseph's brother. |
| Ainsley | | One of Evanna's associates. |
| Aziz | | An Egyptian antiquities ministry agent. |
| Byron | | A lab research director. |
| Gauge | | Ron's second-in-command officer. |
| Gavin | | One of Evanna's associates. |
| Gaythelos | | Meritaten's husband. |
| Irene | | One of Evanna's associates. |
| Meritaten | | The Egyptian princess. Daughter of Pharaoh. |
| Osarseph | | The prophet aided by Meritaten. |
| Phil | | Elise's colleague. |
| Rachel | | One of Evanna's associates. |
| Richard | | One of Evanna's associates. |
| Rondi | | A Salvadoran villager aiding the U.S. scientist. Elise's companion. |
| Ross | | An FBI Agent. Elise's protector. |
