| George | Abbey | Former director of the Johnson Space Center. |
| Aidyn | Aimbetov | A Kazakh cosmonaut. |
| Buzz | Aldrin | An American former astronaut, engineer and fighter pilot. |
| Michael | Alsbury | An American test pilot. |
| Mike | Anderson | An Airforce pilot. |
| Neil | Armstrong | American astronaut and the first person to set foot on the Moon. |
| Jeffrey | Ashby | A naval officer and aviator, test pilot and NASA astronaut. |
| Brian | Babin | A dentist. |
| Helen | Baker | An astronaut. |
| Samuel | Barber | American composer, pianist, conductor, and music educator. |
| Ludwig van | Beethoven | German composer and pianist. |
| Beau | Biden | Vice-President Biden's son. |
| Eric | Boe | American astronaut. |
| Sarah | Brightman | British soprano, musical theatre actress, and dancer. |
| Curt | Brown | One of the senior shuttle commanders. |
| Dave | Brown | A navy pilot. |
| Mikhail | Bulgakov | Russian writer, medical doctor and playwright. |
| Sandra | Bullock | American-German actress and producer. |
| Bob | Cabana | The chief of the astronaut office. |
| Pia | Carosone | Gabby's chief-of-staff. |
| Christopher | Cassidy | The chief of the Astronaut Office at NASA. aka: Chris. |
| Kalpana | Chawla | The first Indian woman in space and an aerospace engineer. |
| Jon | Clark | Laurel Clark's husband. |
| Laurel | Clark | A navy doctor before she became an astronaut. aka: Floral. |
| Jean-Francois | Clervoy | A French astronaut. aka: Billy Bob. |
| Bill | Clinton | 42nd President of the United States. |
| Catherine | Coleman | A retired NASA astronaut. aka: Cady. |
| Eileen | Collins | The first woman to pilot to command U.S. space shuttle. |
| Michael | Collins | American astronaut who flew the Apollo 11 command module. |
| Paul | Conigliaro | The lead flight test engineer. |
| Bob | Crippen | John Young's pilot. |
| Samantha | Cristoforetti | An Italian European Space Agency astronaut. |
| Leonardo | DiCaprio | American actor, film producer, and environmentalist. |
| Alvin | Drew | An astronaut. |
| Tracy Caldwell | Dyson | American chemist and NASA astronaut. |
| Dwight D. | Eisenhower | U. S. Army general, statesman and 34th president of the U. S. |
| Tilman | Fertitta | American businessman and Scott's good friend. |
| Michael | Fincke | American astronaut. aka: Spanky. |
| Roberta | Flack | American singer. |
| Michael | Foale | British-American astrophysicist and former NASA astronaut. |
| Pat | Forrester | Stationed at NASA as an Army officer. |
| Sigmund | Freud | The father of psychoanalysis. |
| Stephen | Frick | American astronaut. aka: Steve. |
| Yuri | Gagarin | A Soviet pilot and cosmonaut. The first human in space. |
| Hoot | Gibson | Scott's acquaintance. |
| Yuri | Gidzenko | Russian cosmonaut. |
| Gabrielle | Gifford | Mark's wife. aka: Gabby. |
| Steve | Gilmore | A new flight surgeon. |
| John | Glenn | The first U.S. astronaut to orbit Earth. |
| Teresa | Gomez | An administrative assistant at the astonaut selection office. |
| Christina T. | Green | A nine-year-old girl who was interested in politics. |
| Alan | Gross | United States government contractor. |
| John M. | Grunsfeld | American astronaut and astronomer. |
| Elena | Hanson | Scott's instructor. |
| Brooke | Heathman | Scott's crew secretary. |
| Charles O. | Hobaugh | NASA astronaut. aka: Scorch. |
| Kara | Hultgreen | U.S. Navy aviator and the first female carrier-based fighter pilot. |
| Rich | Husband | An American astronaut. |
| Gennady | Ivanovich | A Soviet serial killer, rapist and robber. |
| Stonewall | Jackson | General of the Confederate Army in the American Civil War. |
| Jennifer | James | Scott's scheduler. |
| Smith | Johnson | A NASA flight surgeon. |
| Sasha | Kaleri | Russian cosmonaut. |
| Mark | Kelly | Scott's twin brother. |
| Scott Joseph | Kelly | A retired astronaut and naval aviator. |
| Bob | Kelman | Scott's roommate. |
| Genghis | Khan | The founder and first Great Khan of the Mongol Empire. |
| Dmitry | Kondratyev | Russian cosmonaut. aka: Dima. |
| Oleg | Kononenko | A Russian cosmonaut. |
| Tim | Kopra | An Army aviator and engineer. |
| Mikhail | Kornienko | Russian cosmonaut served as a flight engineer on the ISS. |
| Valary | Korzun | Russian cosmonaut. |
| Sergei | Krikalev | Soviet and Russian cosmonaut. |
| Mike | Lammers | The lead flight director. |
| Alfred | Lansing | American journalist and writer. |
| Alfred | Lansing | A writer. |
| Lex | Lauletta | Scott's on-wing instructor. |
| Dave | Leestma | The direct supervisor of the chief astronaut. |
| Alexei | Leonov | Soviet and Russian cosmonaut. |
| Abraham | Lincoln | 16th president of the United States. |
| Kjell | Lindgren | American astronaut currently in the employ of NASA. |
| Steve | Lindsey | The chief of the astronaut office. |
| George | Long | Scott's roommate. |
| Shannon | Lucid | An American astronaut. |
| Ferdinand | Magellan | A Portuguese explorer in the service of Spain. |
| Yuri | Malenchenko | Russian cosmonaut. The first person to marry in space. |
| Jay | Marschke | A capcom. |
| Richard | Mastracchio | American engineer and former NASA astronaut. aka: Rick. |
| Pete | Matthew | One of scott's high school buddies. |
| Megan | McArthur | One of the youngest astronauts. |
| Christa | McAuliffe | American educator and astronaut. |
| Paul | McCartney | English singer, songwriter, bassist of The Beatles. |
| Willie | McCool | A Navy pilot before selected as astonaut. |
| Pamela | Melroy | A retired US Air Force officer and a former NASA astronaut. |
| Brian | Miles | A urologist. |
| Bill | Mnich | Scott's RIO. aka: Smoke. |
| Andreas | Mogensen | ESA astronaut from Denmark. aka: Andy |
| Joel | Montalbano | Serves as the Manager, ISS Program Office. |
| Barbara | Morgan | American teacher and a former NASA astronaut. |
| Wolfgang A. | Mozart | Austrian composer of the Classical period. |
| Paolo | Nespoli | An Italian astronaut. |
| Claude | Nicollier | The first astronaut from Switzerland. |
| Leonard | Nimoy | American actor, film director, author, singer, and songwriter. |
| Dr. | No | The Russian flight doctor. |
| Lisa | Nowak | American naval flight officer and NASA astronaut. |
| Karen | Nyberg | American astronaut. |
| Barack | Obama | 44th President of the United States. |
| Gennady | Padalka | Russian Air Force officer and an RKA cosmonaut. aka: Gena. |
| Scott | Parazynski | A flight engineer. |
| Luca | Parmitano | Italian astronaut. |
| Julie | Payette | A former astronaut who served as Governor General of Canada. |
| Tim | Peake | British Army Air Corps officer and astronaut. |
| David | Petraeus | Retired American military officer and public official. |
| Donald | Pettit | American astronaut. aka: Don. |
| Marl L. | Polansky | American aerospace engineer and former NASA astronaut. |
| Francis Gary | Powers | American pilot shot down flying a spy plane over the Soviet Union. |
| Charlie | Precourt | The new chief of the Astronaut Office. |
| Vladimir | Putin | The current President of Russia. |
| Ilan | Ramon | Israeli fighter pilot and later the first Israeli astronaut. |
| Ronald | Reagan | 40th President of the United States. |
| Steve | Robinson | A capcom. |
| Kent | Rominger | American astronaut. |
| Duane | Ross | One who rans the astronaut selection office. |
| David | Saint-Jacques | Canadian astronaut with the Canadian Space Agency . |
| Philip | Schuyler | American general in the Revolutionary War. |
| Tom | Selleck | American actor and film producer. |
| Alan | Shepard | American astronaut, and the first American to travel into space. |
| Bill | Shepherd | NASA astronaut who served as Commander of Expedition 1. |
| Anton | Shkaplerov | Russian cosmonaut. |
| Oleg | Skripochka | Russian cosmonaut. |
| Deke | Slayton | US Air Force pilot, aeronautical engineer, and test pilot. |
| Steve | Smith | Australian international cricketer. |
| Yi | Soyeon | One of Yuri's female crewmates. |
| Bruce | Springsteen | American musician, singer and composer. |
| Richard | Strauss | German composer and orchestra director. |
| Frederick | Sturckow | A retired U.S. Marine Corps officer, former NASA astronaut. |
| Jerry | Tarnoff | High school principal. |
| Pyotr IIyich | Tchaikovsky | Russian composer. |
| Sergei | Treshchov | Russian cosmonaut. |
| Terry | Virts | A retired NASA astronaut. |
| Sergey | Volkov | Russian cosmonaut and engineer. |
| Shannon | Walker | American scientist and NASA astronaut. |
| William | Wallace | The leader in the Wars for Scottish Independence. |
| Jim | Wetherbee | An astronaut who served as the director of flight crew operations. |
| Douglas H. | Wheelock | American engineer and astronaut. aka: Dough. |
| Peggy | Whitson | Former NASA Chief Astronaut. |
| Dave | Williams | A Canadian astronaut who worked as an ER doctor. |
| Jeffrey | Williams | One of Scott's astronaut's classmates. |
| Stephanie | Wilson | American engineer and NASA astronaut. |
| Thomas | Wolfe | An American author and journalist. |
| Chuck | Woodard | Scott's RIO. aka: Gunny. |
| Leslie | Yandell | Scott's ex-wife. |
| John | Young | The only astronaut to have launched on three different spacecraft. |
| Kimiya | Yui | Japanese astronaut from Japan Aerospace Exploration Agency. |
| Fyodor | Yurchikhin | Russian cosmonaut. |
| Amiko | | Scott's longtime partner. |
| Carroll | | Scott's RIO Ward. aka: Mooch. |
| Charlotte | | One of Scott's daughters. |
| Claire | | Mark's younger daughter. |
| Claudia | | Mark's daughter. |
| Coldplay | | A British band. |
| Corbin | | Amiko's son. |
| Dan | | Scott's uncle. |
| Ephim | | A Russian driver. |
| Gerry | | One of Scott's friends. |
| Helen | | Scott's grandmother. |
| Iain | | Laurel Clark's son. |
| Jenny | | A taxi driver. |
| Joe | | Scott's uncle. |
| Richie | | Scott and Mark's father. |
| Robert | | One of Scott's friends. |
| Samantha | | One of Scott's daughters. |
| Todd | | One of Scott's friends. |
| Tristan | | Amiko's son. |
