| 1 | Miss | Thompson | Megan's teacher. |
| | Megan | McGuire | The student with polio. |
| | Virginia | O'Hanlon-Douglas | The woman who runs New York General Hospital. AKA: Santa Claus Girl. |
| | Valerie | Jackson | Virginia's assistant. |
| | Peggy | Tugucci | Megan's friend. |
| | Nora | McGuire | Megan's mother. |
| 2 | Bill | Lessor | Megan's family doctor. |
| | Neill | Friedman | The doctor who will examine Megan. |
| | Mrs. | Peters | Lessor's secretary. |
| | Gino | Ruganni | Dispatch manager and owner of City Cabs Company. |
| | Willy | | Gino's clerk. |
| | Bobby | Nolan | LaGuardia dispatcher. |
| | Ben | Wilson | Megan's cabbie driver. |
| | Joe | Martinez | Ben's friend. |
| | Brenda | Martinez | Joe's wife. |
| | Hank | McGoran | Joe's business partner. |
| 3 | Sophia | Ruganni | Gino's sister. |
| | Angelina | Ruganni | Gino's sister. |
| | Raphael | Ruganni | Gino's brother. |
| | Anton | Ruganni | Gino's brother. |
| | Maria | Ruganni | Gino's mother. |
| 4 | Sarah Jeanne | Branson | Nora's mother. |
| | John | Williams | Megan's co-patient. |
| 5 | Dan | Kalman | An assignment editor at the telegraph. |
| | Jim | Ellis | A senior new writer. |
| | Mary | Henderson | Dan's co-worker. |
| | Charlie | Crocker | The garden writer. |
| | David | Lindsey | The man who will write about New York General School. |
| 6 | Helen | | Virginia's neighbor. |
| | Bentley | | Helen's dog. |
| 7 | Jeanne | O'Connor | A nurse. |
| | Mike | Reilly | A times reporter. |
| 8 | Ruth | Hoffman | New nurse supervisor. |
| 10 | Philip | O'Hanlon | Virginia's father. |
| | Edward | Mitchell | A senior editor. |
| | Francis | Church | Mitchell's fellow editor. |
| | Willliam | Conant-Church | Francis's brother. Writer of Ulyses Grant biography. |
| | Elizabeth | Church | Francis's wife. |
| 11 | Victor | Polotofsky | One of the leads. |
| | Milos | Pilos | One of the platemakers. |
| 12 | Ed | Bauer | Bauer Manufacturing owner. |
| | Bonnie | Bauer | Ed's wife. |
| | Nick | | The owner of the stand. |
| | George | Furding | The doorman. |
| | Murray | Dolan | A Cab driver. |
| | Rachel | Hall | One of the polio patients. |
| | Alice | Simi | A waitress. |
| | Emil | Stephanos | One of the donors. |
| | Enrico | | Gino's cousin. |
| | Sam | Weinberg | Owner of the Iron Lung Company. |
| 13 | Arlene | Dolan | Murray's sister. |
| | Mary | MacLaren-Dolan | Murray's wife. |
| | Katherine | Dolan | Murray's daughter. |
| | Ellen | Passanisi | Gino's niece. |
| 15 | Charlene | | One of Joe's colleagues. |
| | Phil | Morrton | One of the cabbies. |
| | Fred | Cromwell | A longtime aircraft mechanic. |
| 16 | Amy | Lewis | Scott's mother. |
| | Scott | Lewis | The sick kid. |
| 17 | Sean | Morrow | Emergency Room Physician. |
