| Dr. | Adels | Marilyn's doctor. |
| Edwin | Aldrin | Joan's husband. |
| Joan | Aldrin | The astronauts' neighbor. |
| Neil | Armstrong | Part of the Nine astronauts. |
| Pancho | Barnes | Owner of a bar on Edward Air Force base. |
| Jeanne | Bassett | The astronauts' neighbor. |
| Sue | Bean | The astronauts' neighbor. |
| Del | Berry | Dr. Berry's wife. Trudy's best friend. |
| Lady | Bird | The U.S. first lady. |
| Eugene | Bodin | The French artist. |
| Frank | Borman | Part of the Nine astronauts. |
| Susan | Borman | Frank's wife. |
| Mel | Brooks | A producer and director. |
| Truman | Capote | One of Jane's literary darlings. |
| Bill | Carpenter | The Apollo 11 flight surgeon. |
| Malcolm | Carpenter | One of the Nation's Mercury astronauts. |
| Rene | Carpenter | Scott's wife. |
| Scott | Carpenter Jr. | Scott and Rene's son. |
| Oleg | Cassini | Jackie's designer. |
| Doc | Castor | Annie's father. |
| Barbara | Cernan | Gene's wife. |
| Gene | Cernan | The astronauts' pilot. Aka: Geno. |
| Martha | Chaffee | Roger's wife. |
| Roger | Chaffee | One of the astronauts. |
| Sheryl Lyn | Chaffee | Roger and Martha's daughter. |
| Stephen | Chaffee | Roger and Martha's son. |
| Mike | Collins | One of the astronauts. |
| Nellie | Connally | The first lady of Texas. |
| Charles | Conrad | Part of the Nine astronauts. Aka: Pete. |
| Jane | Conrad | Pete's wife. Aka: Mimi. |
| Gordo | Cooper | Trudy's husband. An astronaut. |
| Hell | Cooper | Gordo's grandmother. |
| Trudy | Cooper | Gordo's wife. A pilot. |
| Leroy | Cooper Jr. | One of the Nation's Mercury astronauts. Aka: Gordo. |
| Jacques | Cousteau | An underwater explorer. |
| Walter | Cronkite | The CBS's reporter. |
| Walt | Cunningham | Gene's colleague. |
| Charles | De Gaulle | The President of France. |
| Dr. Michael | DeBakey | Harriet's friend. |
| Leo | Deorsey | Mercury's astronaut's lawyer. |
| Bill | Douglas | The NASA's flight surgeon. |
| Mr. | DuPont | A real estate owner. |
| Amelia | Earhart | Founder of the Women's Transcontinental Air Race. |
| Donn | Eisele | Harriet's husband. |
| Susie | Eisele | Donn's new wife. |
| President | Eisenhower | The U.S. President. |
| Henry | Fonda | A Hollywood actor. |
| Yuri | Gagarin | A cosmonaut. |
| Bob | Gilruth | Head of NASA. |
| Annie | Glenn | John's wife. |
| John | Glenn Jr. | One of the Nation's Mercury astronauts. |
| T. Keith | Glennan | The man who took the podium. |
| Mrs. | Goddard | Robert Goddard's widow. |
| Robert | Goddard | A rocket pioneer. |
| Samuel | Goldwyn | The administrator of NASA. |
| Betty | Grissom | Gus's wife. |
| Cecile | Grissom | Gus's father. |
| Mitchell | Grissom | Gus's mother. |
| Virgil | Grissom | One of the Nation's Mercury astronauts. Aka: Gus. |
| Dodie | Hamblin | The Life's journalist. |
| James | Holloway Jr. | The 4-star Admiral. Jo's step-father. |
| Popo | I | Buzz's monkey. |
| Lyndon | Johnson | Senator. |
| Janis | Joplin | A famous singer. Marge's friend. |
| Bobby | Kennedy | A Senator. Aka: RFK. |
| Ethel | Kennedy | Bobby's wife. |
| Jackie | Kennedy | Socialite and instant celebrity. |
| John | Kennedy | The new U.S. President. |
| Camala | Keoki | Gordo and Trudy's daughter. |
| Chris | Kraft | The flight director of Apollo 8. |
| Henri | Landwirth | Holiday Inn's manager. |
| Alexey | Leonov | A cosmonaut. |
| Gratia | Lousma | A woman who seeks counsel and comfort from Marge. |
| Jim | Lovell | Part of the Nine astronauts. |
| Marilyn | Lovell | Jim's wife. |
| Lawrence | Marcus | Scion of the Dallas-based dept. store. |
| Catherine | Marshall | The widow of a chaplain of the U.S. senate. |
| Jim | McDivitt | Part of the Nine astronauts. |
| Pat | McDivitt | Jim's wife. |
| Dr. | McGuire | Gratia's doctor. |
| Ralph | Morse | The Life photographer. |
| Richard | Nixon | The U.S. Senator. |
| Dee | O'Hara | The astronauts' nurse. |
| Diaz | Ordaz | The President of Mexico. |
| John | Powers | NASA's press officer. |
| Jim | Rathmann | Owner of Cadillac-Chevrolet dealership. |
| Dr. | Rendezvous | The moniker. |
| Eddie | Rickenbacker | The World War 1 flying ace. |
| Nancy | Robbins | A prominent Houston socialite. |
| Jo | Schirra | Walter's wife. A Navy royalty. |
| Martin | Schirra | Jo and Wall's son. |
| Walter | Schirra | One of the Nation's Mercury astronauts. Aka: Wally. |
| Clare | Schweickart | Pat's friend. |
| Rusty | Schweickart | Clare's husband. An astronaut. |
| Elliot | See | Part of the Nine astronauts. |
| Marilyn | See | Eliott's wife. |
| Julie | Shepard | Louise and Alan's daughter. |
| Laura | Shepard | Louise and Alan's daughter. |
| Louise | Shepard | Alan's wife. |
| Polly | Shepard | Alan's sister. |
| Alan | Shepard Jr. | One of the Nation's Mercury astronauts. |
| Donald | Slayton | Marge's husband. One of the Nation's Mercury astronauts. Aka: Deke. |
| Kent | Slayton | Marge and Deke's son. |
| Marge | Slayton | Donald's wife. |
| Valerie | Solahan | A SCUM member who shot Andy Warhol. |
| Dr. | Spock | The childcare expert. |
| Faye | Stafford | Tom's wife. Harriet's best friend. |
| Tom | Stafford | Part of the Nine astronauts. |
| Werner | Von Braun | NASA's German rocket scientist. |
| Loudon | Wainwright | The Life ghostwriter. |
| Ed | White | Part of the Nine astronauts. |
| Pat | White | Ed's wife. |
| Barbara | Young | John's wife. |
| John | Young | Part of the Nine astronauts. Gus's partner. |
| Adelin | | Rene's neighbor. |
| Alice | | Louise's niece. |
| Barker | | The Space dog. Aka: Little Curly. |
| Harriet | | Donn's wife. |
| MacDuff | | The Lovell's collie. |
| Nanabelle | | Marge's mother. |
| Susy | | John's mistress. |
| Venus | | Gene's cocker spaniel. |
