| 1 | | | Claire |
| | Danielle | | Claire's secretary. |
| | Rory | Cook | A philanthropist. |
| | Claire | Taylor | Rory's wife. |
| | Petra | Federotov | Claire's friend. |
| | Mrs. | Morris | A government teacher in the twelfth grade. |
| | Nico | | Petra's brother. |
| | Al | Capone | American gangster. |
| | Maggie | Moretti | Rory's ex-girlfriend. |
| | Kate | Lane | A political commentator. |
| | Violet | | Claire's sister. |
| | Marjorie | Cook | A senator. Rory's mother. |
| | Carolyn | Bessette | Wife of John F. Kennedy Jr. |
| | John F. | Kennedy Jr. | President John F. Kennedy's son. |
| | Amanda | Burns | Claire's new name. |
| 2 | | | Claire |
| | Anita | Reynolds | The director of the Center Street Literacy. |
| | Norma | | A chef. |
| | Joshua | | Norma's son. |
| | Bruce | Corcoran | Rory's longtime assistant. |
| | Hillary | Clinton | American politician. |
| | Geraldine | Ferraro | American lawyer and politician. |
| 3 | | | Claire |
| | Constance | | A maid. |
| 4 | | | Eva |
| | Eva | James | Claire's new acquaintance. |
| | David | | Eva's husband. |
| 5 | | | Claire |
| | Hillary | Stanton | NTSB Senior Communications Officer. |
| 6 | | | Eva |
| | Brett | | One of Eva's acquaintances. |
| | Saul | | One of Eva's acquaintances. |
| | Dex | | One of Eva's acquaintances. |
| | Felix | Argyros | Dex's boss. aka: Fish. |
| | Brittany | | Dex's acquaintance. |
| 8 | | | Eva |
| | Mr. | Cosatino | Eva's neighbor |
| | Rachel Ann | James | Eva's mother. |
| | Sister Bernadette | | The nun who raised Eva. |
| | Wade | Robert | Eva's acquaintance. |
| 10 | | | Eva |
| | Danny | | Dex's acquaintance. |
| | Liz | | Eva's friend. |
| 11 | | | Claire |
| | Craig | Henderson | A social worker. |
| 12 | | | Eva |
| | Agent | Castro | A federal DEA officer. |
| | Gabe | | DuPree's manager. |
| | Jeremy | | One of Eva's best clients. |
| 13 | | | Claire |
| | Mary | | Rory's aunt. |
| | Charlie | Flanagan | Former senior accountant with the Cook Foundation. |
| 14 | | | Eva |
| | Ellie | | Liz's daughter. |
| | Emily | | Liz's closest friend. |
| | Bess | | Emily's partner. |
| | Vera | | Bess and Emily's department head. |
| | Dr. | FitzGerald | Considered as the Founding Father of Zone Therapy. |
| | Carmen | | Eva's adoptive mother. |
| | Mark | | Carmen's husband. |
| 15 | | | Claire |
| | Kelly | | Claire's new acquaintance. |
| | Jim | | One of Claire's colleagues. |
| 18 | | | Eva |
| | Nancy | | Rachel Ann's mother. |
| | Erwin | James | Rachel's father |
| | Maxwell | | Rachel's brother. |
| 19 | | | Claire |
| | Jacinta | | Kelly's daughter. |
| | Mel | | Jacinta's friend. |
| | Marilyn | | Kelly's mother. |
| | Jasper | Johns | American painter and sculptor. |
| | Jean-Michel | Basquiat | American artist. |
| | Tom | | Kelly's boss. |
| | Marcy | | A caterer. |
| | Jacqueline K. | Onassis | Former First Lady of the United States. |
| | Donny | Rodriquez | A baseball star. |
| | Cressida | | Donny's girlfriend. |
| 35 | | | Claire |
| | Auguste | Rodin | French sculptor. |
| | Mrs. | Crespi | A friend of Kelly's mother. |
