| | | | Part One: Noelle |
| 2 | | | Tara |
| | Grace | | Sam's daughter. Aka: Gracie. |
| | Samuel | Vincent | A lawyer. Aka: Sam. |
| | Cleveland | Johnson | Grace's boyfriend. Aka: Cleve. |
| | Ian | Cutler | Sam's law partner and close friend. |
| | Noelle | Downie | Tara's friend. |
| | Jenny | Stiles | Grace's best friend. |
| | Tara | Locke | Sam's wife. |
| | Emerson | McGarrity | Tara's best friend. Aka: Em. |
| | Suzanne | Johnson | Cleve's mother. |
| 3 | | | Emerson |
| | Ted | | Emerson's husband. |
| | Matthew | McConaughey | American actor and producer. |
| | Libby | | Noelle's acquaintance. |
| | Patches | | Noelle's cat. |
| | | Whittaker | A police officer. |
| 4 | | | Noelle |
| | James | | Noelle's neighbor. |
| | Bea | | James' girlfriend. |
| | Doreen | | A maid. |
| 5 | | | Tara |
| | Devon | | Jenny's boyfriend. |
| 6 | | | Emerson |
| | Gloria | Massey | An obstetrician. |
| | Laurie | | Gloria Massey's office manager. |
| 7 | | | Noelle |
| | Miss | Wilson | Noelle's mother's friend. |
| | Pops | | Noelle's car. |
| 8 | | | Tara |
| | Twitter | | Tara's dog. |
| | Barbara | Read | Tara's acquaintance. |
| 9 | | | Emerson |
| | Patty | Robinson | Noelle's first patient. |
| 10 | | | Noelle |
| | Luanne | | Noelle's acquaintance. |
| 12 | | | Emerson |
| | Anna | Knightly | The director of the Missing Children's Bureau. |
| 13 | | | Noelle |
| | Frank | McGarrity | Emerson's father. |
| | Susan | Emerson | Emerson's mother. |
| 14 | | | Tara |
| | Tyler | | One of Tara's students. |
| | Mr. | Starkey | The head of the drama club. |
| | Mattie | Cafferty | One of Tara's students. |
| | Meryl | Streep | American actress. |
| | | | Part Two: Anna |
| 16 | | | Anna |
| | Haley Hope | Knightly | Anna's daughter. |
| | Bryan | | Haley's father. |
| | Fred | | A stuffed bear. |
| | George | Clooney | American actor, film producer. |
| | Lily Ann | Knightly | Anna's lost child. |
| | Jeff | Jackson | Haley's oncologist. |
| | Madison | | One of Haley's cousins. |
| | Mandy | | One of Haley's cousins. |
| | Marilyn | Collier | Bryan's sister. |
| 19 | | | Anna |
| | Tom | | One of Haley's nurses. |
| | Megan | | One of Haley's cousins. |
| | Melanie | | One of Haley's cousins. |
| | Doug | Davis | The transplant specialist. |
| 22 | | | Emerson |
| | Sandra | | The restaurant's manager. |
| 24 | | | Tara |
| | Rebecca | Baker | One of Noelle's patients. |
| | Denise | Abernathy | One of Noelle's patients. |
| 26 | | | Tara |
| | Petra | | Rebecca Baker's daughter. |
| | Jane | Rogers | A midwife. |
| 27 | | | Emerson |
| | Leta | | Emerson's great-aunt. |
| 29 | | | Noelle |
| | Zeke | | Suzanne's husband. |
| 30 | | | Tara |
| | Sharon | Byerton | Sam's client. |
| 32 | | | Emerson |
| | Angela | | Noelle's acquaintance. |
| | Rob | | Angela's husband. |
| | | | Part Three: Grace |
| 39 | | | Tara |
| | Elena | | Jenny's friend. |
| 49 | | | Tara |
| | Elaine | Meyers | Worked at the Missing Children's Bureau. |
| 59 | | | Noelle |
| | Clare | Briggs | Noelle's trained companion. |
| | Jill | Kenney | A nurse. |
| | Therese | | Jill's reliever. |
| | Ellen | | A social worker. |
