| Denise | Abernathy | One of Noelle's patients. |
| Rebecca | Baker | One of Noelle's patients. |
| Clare | Briggs | Noelle's trained companion. |
| Sharon | Byerton | Sam's client. |
| Mattie | Cafferty | One of Tara's students. |
| George | Clooney | American actor, film producer. |
| Marilyn | Collier | Bryan's sister. |
| Ian | Cutler | Sam's law partner and close friend. |
| Doug | Davis | The transplant specialist. |
| Noelle | Downie | Tara's friend. |
| Susan | Emerson | Emerson's mother. |
| Jeff | Jackson | Haley's oncologist. |
| Cleveland | Johnson | Grace's boyfriend. Aka: Cleve. |
| Suzanne | Johnson | Cleve's mother. |
| Jill | Kenney | A nurse. |
| Anna | Knightly | The director of the Missing Children's Bureau. |
| Haley Hope | Knightly | Anna's daughter. |
| Lily Ann | Knightly | Anna's lost child. |
| Tara | Locke | Sam's wife. |
| Gloria | Massey | An obstetrician. |
| Matthew | McConaughey | American actor and producer. |
| Emerson | McGarrity | Tara's best friend. Aka: Em. |
| Frank | McGarrity | Emerson's father. |
| Elaine | Meyers | Worked at the Missing Children's Bureau. |
| Barbara | Read | Tara's acquaintance. |
| Patty | Robinson | Noelle's first patient. |
| Jane | Rogers | A midwife. |
| Mr. | Starkey | The head of the drama club. |
| Jenny | Stiles | Grace's best friend. |
| Meryl | Streep | American actress. |
| Samuel | Vincent | A lawyer. Aka: Sam. |
| | Whittaker | A police officer. |
| Miss | Wilson | Noelle's mother's friend. |
| Angela | | Noelle's acquaintance. |
| Bea | | James' girlfriend. |
| Bryan | | Haley's father. |
| Devon | | Jenny's boyfriend. |
| Doreen | | A maid. |
| Elena | | Jenny's friend. |
| Ellen | | A social worker. |
| Fred | | A stuffed bear. |
| Grace | | Sam's daughter. Aka: Gracie. |
| James | | Noelle's neighbor. |
| Laurie | | Gloria Massey's office manager. |
| Leta | | Emerson's great-aunt. |
| Libby | | Noelle's acquaintance. |
| Luanne | | Noelle's acquaintance. |
| Madison | | One of Haley's cousins. |
| Mandy | | One of Haley's cousins. |
| Megan | | One of Haley's cousins. |
| Melanie | | One of Haley's cousins. |
| Patches | | Noelle's cat. |
| Petra | | Rebecca Baker's daughter. |
| Pops | | Noelle's car. |
| Rob | | Angela's husband. |
| Sandra | | The restaurant's manager. |
| Ted | | Emerson's husband. |
| Therese | | Jill's reliever. |
| Tom | | One of Haley's nurses. |
| Twitter | | Tara's dog. |
| Tyler | | One of Tara's students. |
| Zeke | | Suzanne's husband. |
