| Epi | Patrick | O'Hara | Protagonist. AKA: Jack Curtis, GUP. |
| | Maisie | O'Hara | Patrick's niece. AKA: Mary Matterhorn. |
| | Grant Patrick | O'Hara | Patrick's nephew. |
| 1 | John | | Patrick's gay neighbor. |
| | Eduardo | | Patrick's gay neighbor. |
| | Dwayne | | Patrick's gay neighbor. |
| | Greg | O'Hara | Patrick's addicted brother. Maisie and Grant's father. |
| | Joe | | Patrick's lover. Deceased. |
| 2 | Audra | Brackett | Maisie's best friend. |
| | Barry | | Patrick's former classmate. |
| | Clara | O'Hara | Patrick and Greg's sister. |
| 3 | Darren | | Clara's husband. |
| | Anita | | Clara's friend. |
| 4 | Luna | | The diner hostess. |
| | Philip | | Patrick and Greg's former dog. |
| 6 | Audra | McDonald | The 6-time Tony winner. |
| | Lorna | | Dwayne's dog. |
| | Mrs. | Roper | Grant's fashion icon. |
| 8 | Cassie | Everest | The woman who works for Neal. |
| | Neal | | Patrick's agent. |
| | Vanessa | Redgrave | An American actress. |
| | Joan | Didion | An American writer. |
| 10 | Otto | Frank | Anne Frank's father. |
| 11 | Bethany | | Neal's wife. |
| | Paul | Newman | An actor. |
| 12 | Marlene | Dietrich | Patrick's dog. Aka: Bella. |
| 13 | Jeremy | Dykstra | Patrick's colleague. |
| | Malina | Kuhn | Patrick's colleague. |
| | Adam | | Patrick's friend. |
| | Daisy | Morales | Patrick's colleague and friend. |
| | Jeniffer | Skeen | Patrick's colleague and friend. |
| | Chunky | Glasses | One of Patrick's guests. |
| | Emory | | The host at Patrick's party. |
| 17 | Charlie | | One of Grant's schoolmates. |
| 19 | Anne | Heche | A geologist. |
| | Lucy | Jones | A seismologist. |
| | Imani | | Grant's nurse. |
| | Seth | | Joe's nurse. |
| 21 | Kevin | | The man who offered Patrick a coffee. |
| 23 | Mona | | Maisie's Lyft driver. |
| | Gale | | The waiter. |
| 24 | Wang | Chung | A Chinese singer. |
| 25 | Barrack | Obama | The former U.S. President. |
| 28 | Scott | Laberge | A TV network manager. |
| | Dottie | | One of Scott's workers. |
| | Basil | | One of Scott's workers. |
| | Sable | | One of Scott's workers. |
| | Kelsi | | One of Scott's workers. |
| | Quill | | One of Scott's workers. |
| | Brant | | One of Scott's workers. |
| | Abner | | One of Scott's workers. |
| 31 | Kacey | | Patrick's workmate. |
| | Taylor | | One of the stagehands. |
