1 | Don | Tillman | Narrator. Associate Professor. Works at the Genetics Department.
Aka: Donald. |
| Gene | Barrow | Don's friend. Head of the Psychology Department. |
| Claudia | Barrow | Gene's wife. Clinical Psychologist. |
| Eva | | House cleaner. |
| Elizabeth | | Claudia's friend. Computer Scientist. |
| Julie | | Asperger Syndrome Counselor. |
2 | Daphne | Speldewind | Don's friend and neighbor. Afflicted with Alzheimer's disease. |
| Charlotte | Lawrence | Dean at the school where Don and Gene works. a.k.a. Dean. |
3 | Helena | | Personal assistant of Gene. |
| Eugenie | Barrow | Daughter of Gene and Claudia. |
| Carl | Barrow | Half-brother of Eugenie. Gene's son. |
| Laszlo | Hevesi | Works in the Physics Department. |
| Kevin | Yu | Honor student of Don. Caught cheating. |
4 | Craig | | One of the men who attended the Table for Eight, a matchmaking organization. |
|
| Danny | | Also attended the Table for Eight. |
| Olivia | | Anthropologist. |
| Gerry | | Lawyer. |
| Sharon | | Accountant. |
| Maria | | Nurse. |
5 | Fabienne | | Attended the singles party. |
|
| Frances | | Participated at a speed dating activity. |
6 | Rosie | Jarman | PhD Candidate in Psychology. Works part-time at the Marquees of Queensbury bar. |
| Jason | | One of the security personnel at Le Gavroche. |
7 | Esther | | Colleague of Don. |
|
| Bethany | | Dated Don. Vegetarian. |
8 | Phil | Jarman | Rosie's father. |
10 | Eamonn | Hughes | Cardiologist. Went to the same medical school as Rosie's mother. |
| Belinda | Hughes | Eamonn's wife. Nurse. |
11 | Peter | Enticott | Doctor. On the medical faculty at Deakin University. |
| Alan | McPhee | Oncologist. Went to the same medical school as Rosie's mother. Deceased. |
| Natalie | | Alan's daughter. |
| Regina | | Personal Assistant of Dean Lawrence. |
14 | | Collie | Doctor. Same graduating class of Rosie's mother. |
| Brian | Joyce | Doctor. Same graduating class of Rosie's mother. |
| | Walsh | Doctor. Same graduating class of Rosie's mother. |
| Jenny | Broadhurst | Wife of Roderick |
| Roderick | Broadhurst | a.k.a. Rod. Doctor. Same graduating class of Rosie's mother. |
15 | Ralph | Browning | Doctor. Same graduating class of Rosie's mother. |
| Miranda | Ball | Doctor. Same graduating class of Rosie's mother. |
| Gerry | Lucas | Doctor. Same graduating class of Rosie's mother. |
| Martin | van Krieger | Doctor. Same graduating class of Rosie's mother. |
| Anwar | Khan | Doctor. Same graduating class of Rosie's mother. |
| Amghad | | Golf Club boss. |
16 | Bianca | Rivera | Met all the criteria of The Wife Project. |
17 | Stefan | | PhD Candidate in Psychology. Rosie's date. |
| Klara | | Hungarian post doctorate from Physics Department. |
| Michelle | | Don's sister. Deceased. |
19 | | Lefebvre | Professor at Medical Research Institute. |
| Gerhard | von Deyn | Doctor. Same graduating class of Rosie's mother. Deceased. |
| Brigitte | von Deyn | Daughter of Gerhard. |
| Geoffrey | Case | Doctor. Same graduating class of Rosie's mother. Deceased. |
| Isaac | Esler | Psychiatrist |
| Solomon M. | Freyberg | Cosmetic Surgeon. |
20 | Margaret | Case | Geoffrey's mother. |
21 | Gary | Parkinson | Went to the same High School as Don. |
23 | Judy | Esler | Wife of Isaac. |
25 | Frank | | Works as tour guide at World Trade Center Site. |
| Mary | Keneally | Associate Professor of Psychiatry at Columbia University. |
| Dave | | Baseball fan. |
| David | Borenstein | Dean of Medicine at Columbia University. |
28 | Bernadette | O'Connor | Rosie's mother. |
33 | Nick | | Head waiter at Le Gavroche. |
34 | Trevor | Tillman | Don's brother. |